Adaptin N terminal region

Definition

This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles PMID:9261055. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 familyPMID:2495531; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles PMID:2495531.

14 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (14 proteins: gene, accession, name)

• AP1B1
• AP1G1
• AP1G2
• AP2A1
• AP2A2
• AP2B1
• AP3B1
• AP3B2
• AP3D1
• AP4B1
• AP4E1
• COPB1
• COPG1
• COPG2