Seroatlas · Human Serome Atlas

AP1M1

AP-1 complex subunit mu-1

Also known as: AP1M1_HUMAN, AP47, CLAPM2, mu1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXS5
Gene
AP1M1
Ensembl
ENSG00000072958
Chromosome
19
Canonical length
423 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9BXS5|AP1M1
     1  MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL AHGGVRFMWI
    61  KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE ESIRDNFVII YELLDELMDF
   121  GYPQTTDSKI LQEYITQEGH KLETGAPRPP ATVTNAVSWR SEGIKYRKNE VFLDVIESVN
   181  LLVSANGNVL RSEIVGSIKM RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ
   241  CVRLSRFEND RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMIKAKSQ
   301  FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSIKSFPG GKEYLMRAHF
   361  GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK SGYQALPWVR YITQNGDYQL
   421  RTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP1M1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • liver: 78 nTPM
  • testis: 58 nTPM
  • bone marrow: 55 nTPM
  • cerebral cortex: 48 nTPM
  • adipose tissue: 47 nTPM
  • adrenal gland: 45 nTPM

Single-cell type

  • late spermatids: 160 nCPM
  • oocytes: 88 nCPM
  • neutrophil progenitors: 75 nCPM
  • neutrophils: 64 nCPM
  • hepatocytes: 63 nCPM
  • monocyte progenitors: 63 nCPM

Immune cell

  • eosinophil: 245 nTPM
  • non-classical monocyte: 237 nTPM
  • intermediate monocyte: 181 nTPM
  • total PBMC: 174 nTPM
  • T-reg: 162 nTPM
  • naive CD8 T-cell: 148 nTPM

Brain region

  • pons: 80 nTPM
  • cerebral cortex: 79 nTPM
  • hypothalamus: 74 nTPM
  • midbrain: 73 nTPM
  • basal ganglia: 72 nTPM
  • hippocampal formation: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.71
gnomAD missense Z
3.7
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AP1M1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP1M1 as an antibody target. Whether an autoantibody or antibody against AP1M1 could matter depends on whether native AP1M1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP1M1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AP1M1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AP1M1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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