Seroatlas · Human Serome Atlas

EPS15L1

Epidermal growth factor receptor substrate 15-like 1

Also known as: EP15R_HUMAN, eps15R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBC2
Gene
EPS15L1
Ensembl
ENSG00000127527
Chromosome
19
Canonical length
864 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Enables cadherin binding activity. Predicted to be involved in endosomal transport and synaptic vesicle endocytosis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

864 residues, UniProt reviewed canonical sequence.

>Q9UBC2|EPS15L1
     1  MAAPLIPLSQ QIPTGNSLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA
    61  DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSNLNLSMPP PKFHDTSSPL MVTPPSAEAH
   121  WAVRVEEKAK FDGIFESLLP INGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD
   181  RDEFAVAMHL VYRALEKEPV PSALPPSLIP PSKRKKTVFP GAVPVLPASP PPKDSLRSTP
   241  SHGSVSSLNS TGSLSPKHSL KQTQPTVNWV VPVADKMRFD EIFLKTDLDL DGYVSGQEVK
   301  EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK DQFALAMYFI QQKVSKGIDP PQVLSPDMVP
   361  PSERGTPGPD SSGSLGSGEF TGVKELDDIS QEIAQLQREK YSLEQDIREK EEAIRQKTSE
   421  VQELQNDLDR ETSSLQELEA QKQDAQDRLD EMDQQKAKLR DMLSDVRQKC QDETQMISSL
   481  KTQIQSQESD LKSQEDDLNR AKSELNRLQQ EETQLEQSIQ AGRVQLETII KSLKSTQDEI
   541  NQARSKLSQL HESRQEAHRS LEQYDQVLDG AHGASLTDLA NLSEGVSLAE RGSFGAMDDP
   601  FKNKALLFSN NTQELHPDPF QTEDPFKSDP FKGADPFKGD PFQNDPFAEQ QTTSTDPFGG
   661  DPFKESDPFR GSATDDFFKK QTKNDPFTSD PFTKNPSLPS KLDPFESSDP FSSSSVSSKG
   721  SDPFGTLDPF GSGSFNSAEG FADFSQMSKP PPSGPFTSSL GGAGFSDDPF KSKQDTPALP
   781  PKKPAPPRPK PPSGKSTPVS QLGSADFPEA PDPFQPLGAD SGDPFQSKKG FGDPFSGKDP
   841  FVPSSAAKPS KASASGFADF TSVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPS15L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 70 nTPM
  • heart muscle: 42 nTPM
  • cerebellum: 29 nTPM
  • esophagus: 25 nTPM
  • tongue: 24 nTPM
  • hippocampal formation: 24 nTPM

Single-cell type

  • neutrophils: 324 nCPM
  • myonuclei: 253 nCPM
  • retinal ganglion cells: 158 nCPM
  • astrocytes: 141 nCPM
  • cardiomyocytes: 135 nCPM
  • platelets: 132 nCPM

Immune cell

  • neutrophil: 57 nTPM
  • basophil: 54 nTPM
  • eosinophil: 36 nTPM
  • memory B-cell: 21 nTPM
  • naive B-cell: 19 nTPM
  • NK-cell: 19 nTPM

Brain region

  • thalamus: 81 nTPM
  • cerebellum: 76 nTPM
  • hippocampal formation: 69 nTPM
  • midbrain: 65 nTPM
  • amygdala: 65 nTPM
  • basal ganglia: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
1.9
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPS15L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPS15L1 as an antibody target. Whether an autoantibody or antibody against EPS15L1 could matter depends on whether native EPS15L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPS15L1 is annotated at the cell surface, where native EPS15L1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EPS15L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPS15L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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