Seroatlas · Human Serome Atlas

EPN1

Epsin-1

Also known as: EPN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6I3
Gene
EPN1
Ensembl
ENSG00000063245
Chromosome
19
Canonical length
576 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q9Y6I3|EPN1
     1  MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI
    61  WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG
   121  VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS
   181  SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM
   241  AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP
   301  VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV
   361  SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS
   421  AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA
   481  LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP
   541  VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
150 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 150 nTPM
  • stomach: 144 nTPM
  • cerebral cortex: 142 nTPM
  • heart muscle: 140 nTPM
  • liver: 132 nTPM
  • amygdala: 124 nTPM

Single-cell type

  • enterocytes: 367 nCPM
  • late spermatids: 315 nCPM
  • kupffer cells: 254 nCPM
  • esophageal apical cells: 238 nCPM
  • colonocytes: 205 nCPM
  • foveolar cells: 165 nCPM

Immune cell

  • non-classical monocyte: 3.6 nTPM
  • eosinophil: 2.3 nTPM
  • intermediate monocyte: 2.2 nTPM
  • neutrophil: 2.1 nTPM
  • classical monocyte: 1.8 nTPM
  • plasmacytoid DC: 1.8 nTPM

Brain region

  • cerebral cortex: 181 nTPM
  • amygdala: 168 nTPM
  • basal ganglia: 163 nTPM
  • hippocampal formation: 158 nTPM
  • white matter: 131 nTPM
  • thalamus: 121 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.79
gnomAD missense Z
1.34
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPN1 as an antibody target. Whether an autoantibody or antibody against EPN1 could matter depends on whether native EPN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPN1 is annotated at the cell surface, where native EPN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EPN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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