Seroatlas · Human Serome Atlas

AP1M2

AP-1 complex subunit mu-2

Also known as: AP1-mu2, AP1M2_HUMAN, HSMU1B, mu2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6Q5
Gene
AP1M2
Ensembl
ENSG00000129354
Chromosome
19
Canonical length
423 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9Y6Q5|AP1M2
     1  MSASAVFILD VKGKPLISRN YKGDVAMSKI EHFMPLLVQR EEEGALAPLL SHGQVHFLWI
    61  KHSNLYLVAT TSKNANASLV YSFLYKTIEV FCEYFKELEE ESIRDNFVIV YELLDELMDF
   121  GFPQTTDSKI LQEYITQQSN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN
   181  LLVNANGSVL LSEIVGTIKL KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ
   241  CVRLSRFDND RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ
   301  FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPERNV VIWSIKSFPG GKEYLMRAHF
   361  GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK SGYQALPWVR YITQSGDYQL
   421  RTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP1M2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 78 nTPM
  • colon: 63 nTPM
  • duodenum: 60 nTPM
  • rectum: 60 nTPM
  • parathyroid gland: 59 nTPM
  • epididymis: 58 nTPM

Single-cell type

  • esophageal apical cells: 196 nCPM
  • migrating cytotrophoblasts: 179 nCPM
  • enterocytes: 148 nCPM
  • cytotrophoblasts: 142 nCPM
  • colonocytes: 140 nCPM
  • enteric transient amplifying cells: 138 nCPM

Immune cell

  • neutrophil: 7.7 nTPM
  • basophil: 4.3 nTPM
  • eosinophil: 2.7 nTPM
  • total PBMC: 2.7 nTPM
  • non-classical monocyte: 1.4 nTPM
  • intermediate monocyte: 0.6 nTPM

Brain region

  • amygdala: 1 nTPM
  • hypothalamus: 1 nTPM
  • cerebral cortex: 0.8 nTPM
  • midbrain: 0.7 nTPM
  • white matter: 0.7 nTPM
  • cerebellum: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AP1M2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP1M2 as an antibody target. Whether an autoantibody or antibody against AP1M2 could matter depends on whether native AP1M2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP1M2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AP1M2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AP1M2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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