Seroatlas · Human Serome Atlas

RFTN1

Raftlin

Also known as: FLJ23866, KIAA0084, MIG2, Raftlin, RFTN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14699
Gene
RFTN1
Ensembl
ENSG00000131378
Chromosome
3
Canonical length
578 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables double-stranded RNA binding activity. Involved in B cell receptor signaling pathway; membrane raft assembly; and positive regulation of growth rate. Acts upstream of or within dsRNA transport; response to exogenous dsRNA; and toll-like receptor 3 signaling pathway. Located in endosome; membrane raft; and plasma membrane. Part of protein-containing complex. Biomarker of glaucoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q14699|RFTN1
     1  MGCGLNKLEK RDEKRPGNIY STLKRPQVET KIDVSYEYRF LEFTTLSAAE LPGSSAVRLA
    61  SLRDLPAQLL ELYQQGFSLA ALHPFVQPTH EREKTPLEHI FRAILIKKTD RSQKTDLHNE
   121  GYILELDCCS SLDHPTDQKL IPEFIKKIQE AASQGLKFVG VIPQYHSSVN SAGSSAPVST
   181  ANSTEDARDA KNARGDHASL ENEKPGTGDV CSAPAGRNQS PEPSSGPRGE VPLAKQPSSP
   241  SGEGDGGELS PQGVSKTLDG PESNPLEVHE EPLSGKMEIF TLFNKPKSHQ KCRQYYPVTI
   301  PLHVSKNGQT VSGLDANWLE HMSDHFRKGG MLVNAVFYLG IVNDSLHGLT DGVFIFEAVS
   361  TEDSKTIQGY DAIVVEQWTV LEGVEVQTDY VPLLNSLAAY GWQLTCVLPT PVVKTTSEGS
   421  VSTKQIVFLQ RPCLPQKIKK KESKFQWRFS REEMHNRQMR KSKGKLSARD KQQAEENEKN
   481  LEDQSSKAGD MGNCVSGQQQ EGGVSEEMKG PVQEDKGEQL SPGGLLCGVG VEGEAVQNGP
   541  ASHSRALVGI CTGHSNPGED ARDGDAEEVR ELGTVEEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFTN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 110 nTPM
  • lymph node: 109 nTPM
  • thymus: 68 nTPM
  • blood vessel: 64 nTPM
  • adipose tissue: 54 nTPM
  • thyroid gland: 50 nTPM

Single-cell type

  • pdcs: 351 nCPM
  • cdc: 294 nCPM
  • nk-cells: 267 nCPM
  • t-cells: 232 nCPM
  • adipocytes: 215 nCPM
  • fibro-adipogenic progenitors: 198 nCPM

Immune cell

  • non-classical monocyte: 82 nTPM
  • NK-cell: 80 nTPM
  • T-reg: 61 nTPM
  • basophil: 56 nTPM
  • intermediate monocyte: 46 nTPM
  • total PBMC: 38 nTPM

Brain region

  • cerebral cortex: 32 nTPM
  • medulla oblongata: 30 nTPM
  • hypothalamus: 28 nTPM
  • basal ganglia: 23 nTPM
  • white matter: 20 nTPM
  • hippocampal formation: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RFTN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFTN1 as an antibody target. Whether an autoantibody or antibody against RFTN1 could matter depends on whether native RFTN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFTN1 is annotated at the cell surface, where native RFTN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RFTN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RFTN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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