Seroatlas · Human Serome Atlas

MEA1

Male-enhanced antigen 1

Also known as: MEA, MEA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16626
Gene: MEA1
Ensembl: ENSG00000124733
Chromosome: 6
Canonical length: 185 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in male gonad development and spermatogenesis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q16626|MEA1
     1  MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS SEEPEEEQEE
    61  TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI QALGLHLPDP PLESEDEDEE
   121  GATALNNHSS IPMDPEHVEL VKRTMAGVSL PAPGVPAWAR EISDAQWEDV VQKALQARQA
   181  SPAWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

testis: 233 nTPM
cerebral cortex: 114 nTPM
amygdala: 102 nTPM
hypothalamus: 98 nTPM
choroid plexus: 91 nTPM
basal ganglia: 91 nTPM

Single-cell type

late spermatids: 2,898 nCPM
early spermatids: 796 nCPM
late primary spermatocytes: 753 nCPM
esophageal apical cells: 256 nCPM
megakaryocytes: 161 nCPM
esophageal suprabasal cells: 160 nCPM

Immune cell

basophil: 230 nTPM
eosinophil: 215 nTPM
total PBMC: 201 nTPM
memory B-cell: 191 nTPM
naive B-cell: 182 nTPM
non-classical monocyte: 162 nTPM

Brain region

hypothalamus: 73 nTPM
cerebral cortex: 58 nTPM
pons: 56 nTPM
medulla oblongata: 50 nTPM
basal ganglia: 50 nTPM
thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Male enhanced antigen 1
Male enhanced antigen 1 (MEA1)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEA1 as an antibody target. Whether an autoantibody or antibody against MEA1 could matter depends on whether native MEA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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