Seroatlas · Human Serome Atlas

EPS15

Epidermal growth factor receptor substrate 15

Also known as: AF-1P, EPS15_HUMAN, MLLT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P42566
Gene
EPS15
Ensembl
ENSG00000085832
Chromosome
1
Canonical length
896 aa
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

896 residues, UniProt reviewed canonical sequence.

>P42566|EPS15
     1  MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD LILGKIWDLA
    61  DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP PRFHDTSSPL LISGTSAAEL
   121  PWAVKPEDKA KYDAIFDSLS PVNGFLSGDK VKPVLLNSKL PVDILGRVWE LSDIDHDGML
   181  DRDEFAVAMF LVYCALEKEP VPMSLPPALV PPSKRKTWVV SPAEKAKYDE IFLKTDKDMD
   241  GFVSGLEVRE IFLKTGLPST LLAHIWSLCD TKDCGKLSKD QFALAFHLIS QKLIKGIDPP
   301  HVLTPEMIPP SDRASLQKNI IGSSPVADFS AIKELDTLNN EIVDLQREKN NVEQDLKEKE
   361  DTIKQRTSEV QDLQDEVQRE NTNLQKLQAQ KQQVQELLDE LDEQKAQLEE QLKEVRKKCA
   421  EEAQLISSLK AELTSQESQI STYEEELAKA REELSRLQQE TAELEESVES GKAQLEPLQQ
   481  HLQDSQQEIS SMQMKLMEMK DLENHNSQLN WCSSPHSILV NGATDYCSLS TSSSETANLN
   541  EHVEGQSNLE SEPIHQESPA RSSPELLPSG VTDENEVTTA VTEKVCSELD NNRHSKEEDP
   601  FNVDSSSLTG PVADTNLDFF QSDPFVGSDP FKDDPFGKID PFGGDPFKGS DPFASDCFFR
   661  QSTDPFATSS TDPFSAANNS SITSVETLKH NDPFAPGGTV VAASDSATDP FASVFGNESF
   721  GGGFADFSTL SKVNNEDPFR SATSSSVSNV VITKNVFEET SVKSEDEPPA LPPKIGTPTR
   781  PCPLPPGKRS INKLDSPDPF KLNDPFQPFP GNDSPKEKDP EIFCDPFTSA TTTTNKEADP
   841  SNFANFSAYP SEEDMIEWAK RESEREEEQR LARLNQQEQE DLELAIALSK SEISEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPS15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 48 nTPM
  • testis: 45 nTPM
  • spinal cord: 44 nTPM
  • hippocampal formation: 42 nTPM
  • midbrain: 41 nTPM
  • lymph node: 39 nTPM

Single-cell type

  • neutrophils: 754 nCPM
  • melanocytes: 746 nCPM
  • neutrophil progenitors: 604 nCPM
  • adrenal cortex cells: 506 nCPM
  • myonuclei: 448 nCPM
  • corticotrophs: 406 nCPM

Immune cell

  • T-reg: 10 nTPM
  • memory B-cell: 9.8 nTPM
  • memory CD8 T-cell: 8.9 nTPM
  • basophil: 8.5 nTPM
  • MAIT T-cell: 8.4 nTPM
  • eosinophil: 7.2 nTPM

Brain region

  • white matter: 98 nTPM
  • hippocampal formation: 93 nTPM
  • midbrain: 89 nTPM
  • cerebral cortex: 87 nTPM
  • basal ganglia: 84 nTPM
  • thalamus: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPS15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPS15 as an antibody target. Whether an autoantibody or antibody against EPS15 could matter depends on whether native EPS15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPS15 is annotated at the cell surface, where native EPS15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EPS15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EPS15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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