Seroatlas · Human Serome Atlas

SLC2A8

Solute carrier family 2, facilitated glucose transporter member 8

Also known as: GLUT8, GLUTX1, SL2A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NY64
Gene: SLC2A8
Ensembl: ENSG00000136856
Chromosome: 9
Canonical length: 477 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9NY64|SLC2A8
     1  MTPEDPEETQ PLLGPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA IPSLQRAAPP
    61  APRLDDAAAS WFGAVVTLGA AAGGVLGGWL VDRAGRKLSL LLCSVPFVAG FAVITAAQDV
   121  WMLLGGRLLT GLACGVASLV APVYISEIAY PAVRGLLGSC VQLMVVVGIL LAYLAGWVLE
   181  WRWLAVLGCV PPSLMLLLMC FMPETPRFLL TQHRRQEAMA ALRFLWGSEQ GWEDPPIGAE
   241  QSFHLALLRQ PGIYKPFIIG VSLMAFQQLS GVNAVMFYAE TIFEEAKFKD SSLASVVVGV
   301  IQVLFTAVAA LIMDRAGRRL LLVLSGVVMV FSTSAFGAYF KLTQGGPGNS SHVAISAPVS
   361  AQPVDASVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI FPLHVKGVAT GICVLTNWLM
   421  AFLVTKEFSS LMEVLRPYGA FWLASAFCIF SVLFTLFCVP ETKGKTLEQI TAHFEGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 64 nTPM
testis: 61 nTPM
adrenal gland: 45 nTPM
liver: 40 nTPM
colon: 40 nTPM
skeletal muscle: 32 nTPM

Single-cell type

late spermatids: 582 nCPM
late primary spermatocytes: 195 nCPM
decidual stromal cells: 167 nCPM
early spermatids: 152 nCPM
hofbauer cells: 139 nCPM
cytotrophoblasts: 99 nCPM

Immune cell

plasmacytoid DC: 76 nTPM
eosinophil: 17 nTPM
T-reg: 15 nTPM
intermediate monocyte: 14 nTPM
non-classical monocyte: 13 nTPM
myeloid DC: 11 nTPM

Brain region

white matter: 39 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 37 nTPM
spinal cord: 36 nTPM
medulla oblongata: 36 nTPM
midbrain: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC2A8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A8 as an antibody target. Whether an autoantibody or antibody against SLC2A8 could matter depends on whether native SLC2A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A8 is annotated at the cell surface, where native SLC2A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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