SLC25A6

Protein identityUniProt · HPA

UniProt accession

P12236

Gene

SLC25A6

Ensembl

ENSG00000169100

Chromosome

X

Canonical length

298 aa

Protein class

FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>P12236|SLC25A6
     1  MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ YKGIVDCIVR
    61  IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKHTQFW RYFAGNLASG
   121  GAAGATSLCF VYPLDFARTR LAADVGKSGT EREFRGLGDC LVKITKSDGI RGLYQGFSVS
   181  VQGIIIYRAA YFGVYDTAKG MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM
   241  QSGRKGADIM YTGTVDCWRK IFRDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

854 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A6.

Disease | ImmuneIEDB

Conditions an epitope on SLC25A6 was assayed in.

• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.78

gnomAD pLI

0.14

gnomAD missense Z

0.56

OntologyGO

Biological processes

• apoptotic process
• mitochondrial ADP transmembrane transport
• mitochondrial ATP transmembrane transport
• negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Molecular functions

• ATP:ADP antiporter activity

Cellular components

• membrane
• mitochondrial inner membrane
• mitochondrion
• nucleus
• TIM23 mitochondrial import inner membrane translocase complex

Protein domainsUniProt · Pfam · InterPro

• Mitochondrial carrier protein
• ADP/ATP carrier protein, eukaryotic type
• Mitochondrial carrier protein, transmembrane region
• Mitochondrial carrier protein domain superfamily
• Mitochondrial carrier protein

KeywordsUniProt

• Acetylation
• Antiport
• Apoptosis
• ATP-binding
• Host-virus interaction
• Membrane
• Methylation
• Mitochondrion
• Mitochondrion inner membrane
• Nucleotide-binding
• Repeat
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of SLC25A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AP2B1
• SLC25A4
• SLC25A5