Seroatlas · Human Serome Atlas

SNAP91

Clathrin coat assembly protein AP180

Also known as: AP180, AP180_HUMAN, CALM, KIAA0656

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60641
Gene: SNAP91
Ensembl: ENSG00000065609
Chromosome: 6
Canonical length: 907 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to enable several functions, including clathrin adaptor activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in cytosol; postsynaptic density; and presynaptic membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

907 residues, UniProt reviewed canonical sequence.

>O60641|SNAP91
     1  MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN ETNVNIPQMA
    61  DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR NTLFNLSNFL DKSGSHGYDM
   121  STFIRRYSRY LNEKAFSYRQ MAFDFARVKK GADGVMRTMA PEKLLKSMPI LQGQIDALLE
   181  FDVHPNELTN GVINAAFMLL FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF
   241  LTRMTRVSEF LKVAEQVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNNEGSGAPS
   301  PLSKSSPATT VTSPNSTPAK TIDTSPPVDL FATASAAVPV STSKPSSDLL DLQPDFSSGG
   361  AAAAAAPAPP PPAGGATAWG DLLGEDSLAA LSSVPSEAQI SDPFAPEPTP PTTTAEIATA
   421  SASASTTTTV TAVTAEVDLF GDAFAASPGE APAASEGAAA PATPTPVAAA LDACSGNDPF
   481  APSEGSAEAA PELDLFAMKP PETSVPVVTP TASTAPPVPA TAPSPAPAVA AAAAATTAAT
   541  AAATTTTTTS AATATTAPPA LDIFGDLFES TPEVAAAPKP DAAPSIDLFS TDAFSSPPQG
   601  ASPVPESSLT ADLLSVDAFA APSPATTASP AKVDSSGVID LFGDAFGSSA SEPQPASQAA
   661  SSSSASADLL AGFGGSFMAP SPSPVTPAQN NLLQPNFEAA FGTTPSTSSS SSFDPSVFDG
   721  LGDLLMPTMA PAGQPAPVSM VPPSPAMAAS KALGSDLDSS LASLVGNLGI SGTTTKKGDL
   781  QWNAGEKKLT GGANWQPKVA PATWSAGVPP SAPLQGAVPP TSSVPPVAGA PSVGQPGAGF
   841  GMPPAGTGMP MMPQQPVMFA QPMMRPPFGA AAVPGTQLSP SPTPASQSPK KPPAKDPLAD
   901  LNIKDFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAP91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 105 nTPM
cerebral cortex: 86 nTPM
retina: 85 nTPM
hypothalamus: 45 nTPM
hippocampal formation: 41 nTPM
amygdala: 40 nTPM

Single-cell type

thyrotrophs: 548 nCPM
cone photoreceptor cells: 493 nCPM
rod photoreceptor cells: 476 nCPM
brain excitatory neurons: 432 nCPM
lactotrophs: 378 nCPM
corticotrophs: 360 nCPM

Immune cell

plasmacytoid DC: 2.8 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 238 nTPM
cerebellum: 198 nTPM
basal ganglia: 157 nTPM
pons: 154 nTPM
white matter: 152 nTPM
hypothalamus: 138 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.16
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAP91 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AP2B1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAP91 as an antibody target. Whether an autoantibody or antibody against SNAP91 could matter depends on whether native SNAP91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAP91 is annotated at the cell surface, where native SNAP91 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNAP91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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