Seroatlas · Human Serome Atlas

BMP2K

BMP-2-inducible protein kinase

Also known as: BIKe, BMP2K_HUMAN, DKFZp434K0614

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSY1
Gene
BMP2K
Ensembl
ENSG00000138756
Chromosome
4
Canonical length
1161 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1161 residues, UniProt reviewed canonical sequence.

>Q9NSY1|BMP2K
     1  MKKFSRMPKS EGGSGGGAAG GGAGGAGAGA GCGSGGSSVG VRVFAVGRHQ VTLEESLAEG
    61  GFSTVFLVRT HGGIRCALKR MYVNNMPDLN VCKREITIMK ELSGHKNIVG YLDCAVNSIS
   121  DNVWEVLILM EYCRAGQVVN QMNKKLQTGF TEPEVLQIFC DTCEAVARLH QCKTPIIHRD
   181  LKVENILLND GGNYVLCDFG SATNKFLNPQ KDGVNVVEEE IKKYTTLSYR APEMINLYGG
   241  KPITTKADIW ALGCLLYKLC FFTLPFGESQ VAICDGNFTI PDNSRYSRNI HCLIRFMLEP
   301  DPEHRPDIFQ VSYFAFKFAK KDCPVSNINN SSIPSALPEP MTASEAAARK SQIKARITDT
   361  IGPTETSIAP RQRPKANSAT TATPSVLTIQ SSATPVKVLA PGEFGNHRPK GALRPGNGPE
   421  ILLGQGPPQQ PPQQHRVLQQ LQQGDWRLQQ LHLQHRHPHQ QQQQQQQQQQ QQQQQQQQQQ
   481  QQQQQQHHHH HHHHLLQDAY MQQYQHATQQ QQMLQQQFLM HSVYQPQPSA SQYPTMMPQY
   541  QQAFFQQQML AQHQPSQQQA SPEYLTSPQE FSPALVSYTS SLPAQVGTIM DSSYSANRSV
   601  ADKEAIANFT NQKNISNPPD MSGWNPFGED NFSKLTEEEL LDREFDLLRS NRLEERASSD
   661  KNVDSLSAPH NHPPEDPFGS VPFISHSGSP EKKAEHSSIN QENGTANPIK NGKTSPASKD
   721  QRTGKKTSVQ GQVQKGNDES ESDFESDPPS PKSSEEEEQD DEEVLQGEQG DFNDDDTEPE
   781  NLGHRPLLMD SEDEEEEEKH SSDSDYEQAK AKYSDMSSVY RDRSGSGPTQ DLNTILLTSA
   841  QLSSDVAVET PKQEFDVFGA VPFFAVRAQQ PQQEKNEKNL PQHRFPAAGL EQEEFDVFTK
   901  APFSKKVNVQ ECHAVGPEAH TIPGYPKSVD VFGSTPFQPF LTSTSKSESN EDLFGLVPFD
   961  EITGSQQQKV KQRSLQKLSS RQRRTKQDMS KSNGKRHHGT PTSTKKTLKP TYRTPERARR
  1021  HKKVGRRDSQ SSNEFLTISD SKENISVALT DGKDRGNVLQ PEESLLDPFG AKPFHSPDLS
  1081  WHPPHQGLSD IRADHNTVLP GRPRQNSLHG SFHSADVLKM DDFGAVPFTE LVVQSITPHQ
  1141  SQQSQPVELD PFGAAPFPSK Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP2K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 16 nTPM
  • tonsil: 15 nTPM
  • appendix: 13 nTPM
  • spleen: 12 nTPM
  • bone marrow: 11 nTPM
  • rectum: 11 nTPM

Single-cell type

  • microglia: 1,141 nCPM
  • mast cells: 822 nCPM
  • hofbauer cells: 631 nCPM
  • megakaryocyte-erythroid progenitors: 474 nCPM
  • megakaryocyte progenitors: 439 nCPM
  • astrocytes: 433 nCPM

Immune cell

  • neutrophil: 0.9 nTPM
  • non-classical monocyte: 0.8 nTPM
  • memory B-cell: 0.6 nTPM
  • naive B-cell: 0.6 nTPM
  • classical monocyte: 0.5 nTPM
  • myeloid DC: 0.4 nTPM

Brain region

  • hypothalamus: 45 nTPM
  • white matter: 40 nTPM
  • medulla oblongata: 33 nTPM
  • midbrain: 28 nTPM
  • spinal cord: 28 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.22
gnomAD missense Z
0.4
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMP2K in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP2K as an antibody target. Whether an autoantibody or antibody against BMP2K could matter depends on whether native BMP2K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP2K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BMP2K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BMP2K. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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