Seroatlas · Human Serome Atlas

SCYL1

N-terminal kinase-like protein

Also known as: GKLP, HT019, MGC78454, NKTL, NTKL, P105, SCYL1_HUMAN, TAPK, TEIF, TRAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KG9
Gene: SCYL1
Ensembl: ENSG00000142186
Chromosome: 11
Canonical length: 808 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

808 residues, UniProt reviewed canonical sequence.

>Q96KG9|SCYL1
     1  MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV
    61  AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG
   121  LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE
   181  LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY
   241  CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS
   301  LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS
   361  TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN
   421  EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF
   481  APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV
   541  SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ
   601  RPTPEGVPAP APTPVPATPT TSGHWETQEE DKDTAEDSST ADRWDDEDWG SLEQEAESVL
   661  AQQDDWSTGG QVSRASQVSN SDHKSSKSPE SDWSSWEAEG SWEQGWQEPS SQEPPPDGTR
   721  LASEYNWGGP ESSDKGDPFA TLSARPSTQP RPDSWGEDNW EGLETDSRQV KAELARKKRE
   781  ERRREMEAKR AERKVAKGPM KLGARKLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCYL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 101 nTPM
liver: 80 nTPM
adrenal gland: 68 nTPM
pancreas: 60 nTPM
heart muscle: 56 nTPM
cerebral cortex: 54 nTPM

Single-cell type

syncytiotrophoblasts: 196 nCPM
extravillous trophoblasts: 110 nCPM
epididymal principal cells: 95 nCPM
cytotrophoblasts: 87 nCPM
breast lactating cells: 85 nCPM
migrating cytotrophoblasts: 77 nCPM

Immune cell

neutrophil: 42 nTPM
eosinophil: 28 nTPM
myeloid DC: 24 nTPM
classical monocyte: 21 nTPM
memory CD8 T-cell: 21 nTPM
gdT-cell: 21 nTPM

Brain region

cerebral cortex: 68 nTPM
white matter: 58 nTPM
hippocampal formation: 58 nTPM
thalamus: 57 nTPM
choroid plexus: 57 nTPM
amygdala: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCYL1.

Disease | AllUniProt

Conditions SCYL1 is implicated in, by any mechanism.

Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21) MIM:616719

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 297 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome
Inborn genetic diseases
SCYL1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCYL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCYL1 as an antibody target. Whether an autoantibody or antibody against SCYL1 could matter depends on whether native SCYL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCYL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCYL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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