Seroatlas · Human Serome Atlas

NUMB

Protein numb homolog

Also known as: C14orf41, NUMB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49757
Gene: NUMB
Ensembl: ENSG00000133961
Chromosome: 14
Canonical length: 651 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

651 residues, UniProt reviewed canonical sequence.

>P49757|NUMB
     1  MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED
    61  AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD
   121  RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA
   181  TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS
   241  SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE
   301  LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ
   361  SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS
   421  SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS
   481  PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG
   541  TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA
   601  DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUMB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

lung: 50 nTPM
liver: 48 nTPM
small intestine: 44 nTPM
duodenum: 44 nTPM
colon: 43 nTPM
placenta: 41 nTPM

Single-cell type

neutrophils: 2,516 nCPM
monocytes: 522 nCPM
renal collecting duct intercalated cells: 436 nCPM
proximal tubule cells: 382 nCPM
sertoli cells: 334 nCPM
neutrophil progenitors: 279 nCPM

Immune cell

neutrophil: 292 nTPM
non-classical monocyte: 104 nTPM
eosinophil: 97 nTPM
classical monocyte: 93 nTPM
basophil: 92 nTPM
intermediate monocyte: 76 nTPM

Brain region

cerebral cortex: 43 nTPM
choroid plexus: 40 nTPM
hippocampal formation: 37 nTPM
medulla oblongata: 37 nTPM
cerebellum: 36 nTPM
thalamus: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUMB.

Disease | ImmuneIEDB

Conditions an epitope on NUMB was assayed in.

colorectal cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.37
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUMB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUMB as an antibody target. Whether an autoantibody or antibody against NUMB could matter depends on whether native NUMB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUMB is annotated at the cell surface, where native NUMB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NUMB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...