MAGE homology domain, winged helix WH1 motif
IPR041898
Definition
This superfamily includes MAGE (melanoma antigen-encoding gene) proteins, which are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function is currently unknown. This superfamily also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex and interacts with NSE4/EID family proteins [[cite:PMID:21364888], [cite:PMID:22536443]]. Nse3 has been demonstrated to be important in meiosis PMID:15331764. MAGE proteins share a conserved domain known as the MAGE homology domain (MHD). This superfamily entry represents the domain that contains a winged helix motif WH1.
35 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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