GALK2

Protein identityUniProt · HPA

UniProt accession

Q01415

Gene

GALK2

Ensembl

ENSG00000156958

Chromosome

15

Canonical length

458 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. The encoded protein is a member of the GHMP kinase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q01415|GALK2
     1  MATESPATRR VQVAEHPRLL KLKEMFNSKF GSIPKFYVRA PGRVNIIGEH IDYCGYSVLP
    61  MAVEQDVLIA VEPVKTYALQ LANTNPLYPD FSTSANNIQI DKTKPLWHNY FLCGLKGIQE
   121  HFGLSNLTGM NCLVDGNIPP SSGLSSSSAL VCCAGLVTLT VLGRNLSKVE LAEICAKSER
   181  YIGTEGGGMD QSISFLAEEG TAKLIEFSPL RATDVKLPSG AVFVIANSCV EMNKAATSHF
   241  NIRVMECRLA AKLLAKYKSL QWDKVLRLEE VQAKLGISLE EMLLVTEDAL HPEPYNPEEI
   301  CRCLGISLEE LRTQILSPNT QDVLIFKLYQ RAKHVYSEAA RVLQFKKICE EAPENMVQLL
   361  GELMNQSHMS CRDMYECSCP ELDQLVDICR KFGAQGSRLT GAGWGGCTVS MVPADKLPSF
   421  LANVHKAYYQ RSDGSLAPEK QSLFATKPGG GALVLLEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

-0.39

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate metabolic process
• galactose metabolic process

Molecular functions

• ATP binding
• galactokinase activity
• N-acetylgalactosamine kinase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Galactokinase
• GHMP kinase, ATP-binding, conserved site
• GHMP kinase N-terminal domain
• Mevalonate/galactokinase
• GHMP kinase, C-terminal domain
• Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
• Galactokinase, N-terminal domain
• Galactokinase, conserved site
• Ribosomal protein uS5 domain 2-type superfamily
• GHMP kinase, C-terminal domain superfamily
• GHMP kinases N terminal domain
• GHMP kinases C terminal
• Galactokinase galactose-binding signature

KeywordsUniProt

• ATP-binding
• Kinase
• Nucleotide-binding
• Transferase