EXOSC6

Protein identityUniProt · HPA

UniProt accession

Q5RKV6

Gene

EXOSC6

Ensembl

ENSG00000223496

Chromosome

16

Canonical length

272 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q5RKV6|EXOSC6
     1  MPGDHRRIRG PEESQPPQLY AADEEEAPGT RDPTRLRPVY ARAGLLSQAK GSAYLEAGGT
    61  KVLCAVSGPR QAEGGERGGG PAGAGGEAPA ALRGRLLCDF RRAPFAGRRR RAPPGGCEER
   121  ELALALQEAL EPAVRLGRYP RAQLEVSALL LEDGGSALAA ALTAAALALA DAGVEMYDLV
   181  VGCGLSLAPG PAPTWLLDPT RLEEERAAAG LTVALMPVLN QVAGLLGSGE GGLTESWAEA
   241  VRLGLEGCQR LYPVLQQSLV RAARRRGAAA QP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOSC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0.52

gnomAD missense Z

-0.59

DepMap mean gene effect

-1.32

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA deamination
• isotype switching
• nuclear mRNA surveillance
• poly(A)-dependent snoRNA 3'-end processing
• positive regulation of isotype switching
• RNA catabolic process
• RNA processing
• rRNA catabolic process
• rRNA processing
• U4 snRNA 3'-end processing

Molecular functions

• RNA binding

Cellular components

• cytoplasmic exosome (RNase complex)
• cytosol
• exosome (RNase complex)
• nuclear exosome (RNase complex)
• nucleolar exosome (RNase complex)
• nucleolus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Exoribonuclease, phosphorolytic domain 1
• Ribosomal protein uS5 domain 2-type superfamily
• PNPase/RNase PH domain superfamily
• Exoribonuclease, PH domain 2 superfamily
• Ribonuclease PH
• 3' exoribonuclease family, domain 1

KeywordsUniProt

• Cytoplasm
• Exosome
• Nucleus
• RNA-binding
• rRNA processing

InteractionsUniProt · HPA

Protein binding partners of EXOSC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EXOSC1
• EXOSC7
• EXOSC8
• EXOSC2
• EXOSC3
• EXOSC4
• EXOSC5
• MPHOSPH6