HSP90AA2P
Heat shock protein HSP 90-alpha A2
Also known as: HS902_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for HSP90AA2P in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
343 residues, UniProt reviewed canonical sequence.
>Q14568|HSP90AA2P
1 MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIW
61 YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME
121 ALQAGADISM IGQFGVSFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGERM
181 GRGTKVILHL KEDQTEYLEE QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED
241 KEEEKEKEEK ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP
301 DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HSP90AA2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about HSP90AA2P.
Disease | ImmuneIEDB
Conditions an epitope on HSP90AA2P was assayed in.
- multiple sclerosis B cell
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Heat shock protein Hsp90 family
- Histidine kinase/HSP90-like ATPase domain
- Heat shock protein Hsp90, conserved site
- Ribosomal protein uS5 domain 2-type superfamily
- Heat shock protein Hsp90, N-terminal
- Histidine kinase/HSP90-like ATPase superfamily
- Hsp90 protein
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HSP90AA2P as an antibody target. Whether an autoantibody or antibody against HSP90AA2P could matter depends on whether native HSP90AA2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HSP90AA2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HSP90AA2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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