Seroatlas · Human Serome Atlas

MVD

Diphosphomevalonate decarboxylase

Also known as: MPD, MVD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P53602
Gene: MVD
Ensembl: ENSG00000167508
Chromosome: 16
Canonical length: 400 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cell Junctions,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>P53602|MVD
     1  MASEKPLAAV TCTAPVNIAV IKYWGKRDEE LVLPINSSLS VTLHQDQLKT TTTAVISKDF
    61  TEDRIWLNGR EEDVGQPRLQ ACLREIRCLA RKRRNSRDGD PLPSSLSCKV HVASVNNFPT
   121  AAGLASSAAG YACLAYTLAR VYGVESDLSE VARRGSGSAC RSLYGGFVEW QMGEQADGKD
   181  SIARQVAPES HWPELRVLIL VVSAEKKLTG STVGMRASVE TSPLLRFRAE SVVPARMAEM
   241  ARCIRERDFP SFAQLTMKDS NQFHATCLDT FPPISYLNAI SWRIIHLVHR FNAHHGDTKV
   301  AYTFDAGPNA VIFTLDDTVA EFVAAVWHGF PPGSNGDTFL KGLQVRPAPL SAELQAALAM
   361  EPTPGGVKYI IVTQVGPGPQ ILDDPCAHLL GPDGLPKPAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MVD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

liver: 83 nTPM
esophagus: 78 nTPM
skin: 51 nTPM
adrenal gland: 50 nTPM
spinal cord: 46 nTPM
cerebral cortex: 44 nTPM

Single-cell type

epididymal principal cells: 350 nCPM
esophageal apical cells: 229 nCPM
esophageal suprabasal cells: 214 nCPM
late spermatids: 165 nCPM
breast lactating cells: 141 nCPM
colonocytes: 140 nCPM

Immune cell

NK-cell: 29 nTPM
plasmacytoid DC: 28 nTPM
gdT-cell: 27 nTPM
naive B-cell: 23 nTPM
MAIT T-cell: 21 nTPM
T-reg: 20 nTPM

Brain region

pons: 62 nTPM
medulla oblongata: 46 nTPM
cerebral cortex: 42 nTPM
midbrain: 37 nTPM
hypothalamus: 37 nTPM
cerebellum: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MVD.

Disease | AllUniProt

Conditions MVD is implicated in, by any mechanism.

Porokeratosis 7, multiple types (POROK7) MIM:614714

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 130 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Porokeratosis 7, multiple types
MVD-related disorder
Linear porokeratosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.47
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
Hsp70 protein binding
protein homodimerization activity
diphosphomevalonate decarboxylase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Ribosomal protein uS5 domain 2-type superfamily
GHMP kinase, C-terminal domain superfamily
Diphosphomevalonate/phosphomevalonate decarboxylase
Diphosphomevalonate decarboxylase
Mvd1, C-terminal
Diphosphomevalonate decarboxylase-like N-terminal domain
Mevalonate 5-diphosphate decarboxylase C-terminal domain
Diphosphomevalonate decarboxylase-like N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MVD as an antibody target. Whether an autoantibody or antibody against MVD could matter depends on whether native MVD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MVD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MVD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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