Seroatlas · Human Serome Atlas

HSP90AB3P

Putative heat shock protein HSP 90-beta-3

Also known as: H90B3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58FF7
Gene: HSP90AB3P
Canonical length: 597 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for HSP90AB3P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q58FF7|HSP90AB3P
     1  MPEEVHHGEE EVETFAFQAE IAQLISLIIN TFYSNEEIFL QELISNASDA LDKIRYESLT
    61  DPSKLDSGKE LKIDIIPNPQ ERTLALVDTG IGMTKADLIN NLRTIAKSGT KACMEALQAE
   121  KLVVITKHND DEQYAWESSA GGSFTVHADH GEPIGRGTKV ILHLKEDQTE YLEERRVKEV
   181  VKKHSQFIGY PITLYLEKEQ DKEISDDEAE EEKGEKEEED KDDEEKPKIK DVGSDEEDDS
   241  KEYGEFYKSL TSDWEDHLAV KHFSVEGQLE FRALLFSPRR APFDLFENKK KKNNIKLYVR
   301  RVFIMDSCDE LIPEYLNFIH GVVDSEDLPL NISREMLQQS KILKYVSHMK ETQKSTYYIT
   361  GESKEQVANS AFVERVRKQG FEVVYMTEPI DEYCVQQLKE FDGKSLVSVT KEGLELPEDE
   421  EEKKKMEESK EKFENLCKLM KEILDKKVEK VTISNRLVSS PCCIVTSTYG WTANMEQIMK
   481  AQALRDNSTM GYMMAKKHLE INPDHPIMET LRQKAEADKN DKAVKDLVVL LFETALLSSG
   541  FSLEDPQTHS NHIYHMIKLG LGTDEDEVAA EEPSDAVPDE IPPLEGDEDA SRMEEVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90AB3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSP90AB3P.

Disease | ImmuneIEDB

Conditions an epitope on HSP90AB3P was assayed in.

multiple sclerosis B cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSP90AB3P as an antibody target. Whether an autoantibody or antibody against HSP90AB3P could matter depends on whether native HSP90AB3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSP90AB3P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSP90AB3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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