Seroatlas · Human Serome Atlas

EXOSC7

Exosome complex component RRP42

Also known as: EAP1, EXOS7_HUMAN, hRrp42p, KIAA0116, p8, RRP42, Rrp42p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15024
Gene: EXOSC7
Ensembl: ENSG00000075914
Chromosome: 3
Canonical length: 291 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in RNA catabolic process and RNA processing. Located in cytosol and nucleolus. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q15024|EXOSC7
     1  MASVTLSEAE KVYIVHGVQE DLRVDGRGCE DYRCVEVETD VVSNTSGSAR VKLGHTDILV
    61  GVKAEMGTPK LEKPNEGYLE FFVDCSASAT PEFEGRGGDD LGTEIANTLY RIFNNKSSVD
   121  LKTLCISPRE HCWVLYVDVL LLECGGNLFD AISIAVKAAL FNTRIPRVRV LEDEEGSKDI
   181  ELSDDPYDCI RLSVENVPCI VTLCKIGYRH VVDATLQEEA CSLASLLVSV TSKGVVTCMR
   241  KVGKGSLDPE SIFEMMETGK RVGKVLHASL QSVVHKEESL GPKRQKVGFL G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOSC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

skin: 43 nTPM
skeletal muscle: 43 nTPM
adrenal gland: 42 nTPM
choroid plexus: 35 nTPM
tongue: 34 nTPM
esophagus: 26 nTPM

Single-cell type

renal collecting duct intercalated cells: 181 nCPM
cardiomyocytes: 167 nCPM
oocytes: 129 nCPM
adrenal cortex cells: 76 nCPM
basal keratinocytes: 76 nCPM
decidual stromal cells: 75 nCPM

Immune cell

memory B-cell: 72 nTPM
myeloid DC: 66 nTPM
naive B-cell: 60 nTPM
NK-cell: 59 nTPM
naive CD4 T-cell: 52 nTPM
T-reg: 48 nTPM

Brain region

hypothalamus: 10 nTPM
choroid plexus: 9.7 nTPM
medulla oblongata: 9 nTPM
cerebral cortex: 8.6 nTPM
pons: 8.4 nTPM
thalamus: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.94
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOSC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOSC7 as an antibody target. Whether an autoantibody or antibody against EXOSC7 could matter depends on whether native EXOSC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOSC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOSC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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