Seroatlas · Human Serome Atlas

EXOSC4

Exosome complex component RRP41

Also known as: EXOS4_HUMAN, FLJ20591, hRrp41p, p12A, RRP41, RRP41A, Rrp41p, SKI6, Ski6p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPD3
Gene
EXOSC4
Ensembl
ENSG00000178896
Chromosome
8
Canonical length
245 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Enables mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including DNA deamination; maturation of 5.8S rRNA; and nuclear-transcribed mRNA catabolic process. Acts upstream of or within defense response to virus. Located in cytosol; euchromatin; and nuclear lumen. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q9NPD3|EXOSC4
     1  MAGLELLSDQ GYRVDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA VVYGPHEIRG
    61  SRARALPDRA LVNCQYSSAT FSTGERKRRP HGDRKSCEMG LQLRQTFEAA ILTQLHPRSQ
   121  IDIYVQVLQA DGGTYAACVN AATLAVLDAG IPMRDFVCAC SAGFVDGTAL ADLSHVEEAA
   181  GGPQLALALL PASGQIALLE MDARLHEDHL ERVLEAAAQA ARDVHTLLDR VVRQHVREAS
   241  ILLGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOSC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • testis: 94 nTPM
  • liver: 36 nTPM
  • adrenal gland: 31 nTPM
  • esophagus: 28 nTPM
  • choroid plexus: 27 nTPM
  • basal ganglia: 26 nTPM

Single-cell type

  • other brain neurons: 7.9 nCPM
  • oligodendrocytes: 6 nCPM
  • brain excitatory neurons: 5.7 nCPM
  • brain inhibitory neurons: 5.4 nCPM
  • oligodendrocyte progenitor cells: 4.4 nCPM
  • astrocytes: 4 nCPM

Immune cell

  • plasmacytoid DC: 91 nTPM
  • classical monocyte: 77 nTPM
  • intermediate monocyte: 75 nTPM
  • myeloid DC: 74 nTPM
  • naive B-cell: 57 nTPM
  • memory B-cell: 55 nTPM

Brain region

  • cerebral cortex: 35 nTPM
  • basal ganglia: 24 nTPM
  • cerebellum: 24 nTPM
  • medulla oblongata: 24 nTPM
  • thalamus: 24 nTPM
  • choroid plexus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0.07
gnomAD missense Z
0.56
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOSC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOSC4 as an antibody target. Whether an autoantibody or antibody against EXOSC4 could matter depends on whether native EXOSC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOSC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOSC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOSC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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