Seroatlas · Human Serome Atlas

HSP90AA4P

Putative heat shock protein HSP 90-alpha A4

Also known as: HS904_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58FG1
Gene: HSP90AA4P
Canonical length: 418 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for HSP90AA4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q58FG1|HSP90AA4P
     1  MESLTDPSKL DSGKEPHISL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI TKSETKVFME
    61  VLQAGADISM IGQFSVGFYS AYSVAEKVTV ITKHNNDEQY AWESSLRGSF TEYREFYKSL
   121  TINWEDYLAV KHFSVEGQLE FRAFLFVPRL APFELLETRK KKNKIKLSAR RDLIMDNCEE
   181  LIPEYLNFIR GVVDSEDLPL NIFRETKDQV ANSTIVQRLW KHGLEVIYTI EPIDEYCVQQ
   241  LKEFEGKTLV SVTKEDLELP EDEEEKKKQE EGKQKTKQKK NQSLRTSAKS TYGWTANMER
   301  IMKAQALRDN STTGYMAAKK HLEINPDHSF IDTLRQKAET DKNDKSVKDL VILLYETALL
   361  SSDFGLEGPQ THANRIYRMN KLGLGTDEDD PTADDTSAAV TEEMPPLEGD DDTSRMEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90AA4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42

OntologyGO

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSP90AA4P as an antibody target. Whether an autoantibody or antibody against HSP90AA4P could matter depends on whether native HSP90AA4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSP90AA4P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSP90AA4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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