Seroatlas · Human Serome Atlas

HSP90AA5P

Putative heat shock protein HSP 90-alpha A5

Also known as: HS905_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58FG0
Gene: HSP90AA5P
Canonical length: 334 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for HSP90AA5P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q58FG0|HSP90AA5P
     1  MGFHHVGQAG LELLTSGHPA LERRPEYLEE RRIKEIVKKH SQFIGYPITL FVEKKRNKQV
    61  SDAEAEKKED KRKKKKESND KPEIEDVGSD EEEEKKDADK KKKKSKEKYI DQELNKTKPI
   121  WTRNPDAITN EEYGEFHQSL TNNWEDHLAV KHFSVEGQLE ELKDSRRVMK ANQKHIYYIT
   181  GETKDQVANS AFVECLQKHG LEVIYMIELI DKYCVQQLKE LESKTVVSVA KEGLELPEDE
   241  EEKKKQEEKK TKFENLCKIM KDMLEKKVKK VVVSNCMEDP QRHTNKIYRM IKLGLGVDEY
   301  DPTANDINAA ITKEMPPLRG GDDTSRMEEV GGSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90AA5P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47

OntologyGO

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSP90AA5P as an antibody target. Whether an autoantibody or antibody against HSP90AA5P could matter depends on whether native HSP90AA5P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSP90AA5P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSP90AA5P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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