Seroatlas · Human Serome Atlas

HSP90AB2P

Putative heat shock protein HSP 90-beta 2

Also known as: H90B2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58FF8
Gene: HSP90AB2P
Canonical length: 381 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for HSP90AB2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q58FF8|HSP90AB2P
     1  MPEEVHLGEK EVETFAFQAE IAQLMSLIIN TFYSNKEIFL WELISNASDA LDKIRYESLT
    61  DPSKLDSGKE LKIDIIPNTQ EHTLTLVDTG IGMTKADLIN NLGTIAKFQD QTEYLEEMQV
   121  KEVVEKHSQF LGYPITLYLE KEREKEISDG KAEEEKGEKE EENKDDEEKP KIEDVGSDEE
   181  DDSGKDKKKK TKKIKEKYID QEELNKTKPI WTRNTEDITQ EEYGEFYKSL TNDWKDHLAV
   241  RYFSVEEYVS RMKEIQKSIY YITGESKEQV ANSAFVEQVW KRDSRVVYMT EPIDGYQLKE
   301  FDGKSLVSVT KEGLELPEDG EEKKRMEERK AKFENLCKFM KETLDKKVEM VTVSNRLVSS
   361  SCCIVTSTYS WTANMEQIMK A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90AB2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSP90AB2P.

Disease | ImmuneIEDB

Conditions an epitope on HSP90AB2P was assayed in.

multiple sclerosis B cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSP90AB2P as an antibody target. Whether an autoantibody or antibody against HSP90AB2P could matter depends on whether native HSP90AB2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSP90AB2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSP90AB2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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