Seroatlas · Human Serome Atlas

HSP90AB4P

Putative heat shock protein HSP 90-beta 4

Also known as: H90B4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58FF6
Gene: HSP90AB4P
Canonical length: 505 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for HSP90AB4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q58FF6|HSP90AB4P
     1  MSLIINTFYS NKEIFLQELI SNASDALDKI RYESLTDPSK LDGGKELKID IIPNPRECIL
    61  TLVNTGIGMT KADLINNLGA IAKSGTEAFM EAFQSCAEIS MIGQFGVGFY SAYLVAEKVA
   121  ITKHNDEEQY SWVSSAGSSF TLHVDHGEPI DRDTKVILHL KEDQTEYLEE RWVKEVVKKH
   181  PQFIGCLIAV YLEKEPEKEI SDDEEEKGEK EEEDKDDKEK PKTEDVGSDE EDDTDKNNKK
   241  KTKKIKEKYT DREELNQTKP IWTRNPDDIT QEECGEFYKS LTSAWEDHLA VKQFPVEEQE
   301  ENEQLCVHHV WIMDSFDDLM PEYVGFVRED KENNKKLDEV FSKISWLGIH EDSINWRHLS
   361  ELLWSHTFQS GDEMTSLSEY VSCMKEAQKS ICDIIGECKE QVANSAFVEQ EWKKGFEVIY
   421  MSEPIDEYCV QQLKEFDGKS LLSVTKEGLE LPEDEEEKKI MEESNVKFEN LCRLMKEILD
   481  KKVERVTISS RLVSSPCRIV TSTYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90AB4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSP90AB4P as an antibody target. Whether an autoantibody or antibody against HSP90AB4P could matter depends on whether native HSP90AB4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSP90AB4P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSP90AB4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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