Seroatlas · Human Serome Atlas

ITGB5

Integrin beta-5

Also known as: ITB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18084
Gene
ITGB5
Ensembl
ENSG00000082781
Chromosome
3
Canonical length
799 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Mitochondria

OverviewNCBI Gene

This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

799 residues, UniProt reviewed canonical sequence.

>P18084|ITGB5
     1  MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI
    61  TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP
   121  GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG
   181  SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS
   241  RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
   301  HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL
   361  DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD
   421  TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG
   481  TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF
   541  GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ
   601  ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL
   661  CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA
   721  MTILLAVVGS ILLVGLALLA IWKLLVTIHD RREFAKFQSE RSRARYEMAS NPLYRKPIST
   781  HTVDFTFNKF NKSYNGTVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
290 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 290 nTPM
  • adipose tissue: 97 nTPM
  • skin: 84 nTPM
  • placenta: 77 nTPM
  • cervix: 73 nTPM
  • breast: 68 nTPM

Single-cell type

  • platelets: 420 nCPM
  • podocytes: 309 nCPM
  • hofbauer cells: 230 nCPM
  • distal convoluted tubule cells: 223 nCPM
  • hepatic stellate cells: 194 nCPM
  • choroid plexus epithelial cells: 187 nCPM

Immune cell

  • total PBMC: 2.5 nTPM
  • gdT-cell: 0.9 nTPM
  • myeloid DC: 0.4 nTPM
  • basophil: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • choroid plexus: 139 nTPM
  • medulla oblongata: 71 nTPM
  • white matter: 63 nTPM
  • midbrain: 60 nTPM
  • basal ganglia: 59 nTPM
  • spinal cord: 58 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ITGB5.

Disease | ImmuneIEDB

Conditions an epitope on ITGB5 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
1.06
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITGB5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGB5 as an antibody target. Whether an autoantibody or antibody against ITGB5 could matter depends on whether native ITGB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGB5 is annotated at the cell surface, where native ITGB5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITGB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITGB5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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