PLXNA3

Protein identityUniProt · HPA

UniProt accession

P51805

Gene

PLXNA3

Ensembl

ENSG00000130827

Chromosome

X

Canonical length

1871 aa

Protein class

Plasma proteins, Predicted membrane proteins

Subcellular location

Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

1871 residues, UniProt reviewed canonical sequence.

>P51805|PLXNA3
     1  MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL
    61  TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL LIDYAARRLV ACGSIWQGIC
   121  QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT
   181  LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT
   241  LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP
   301  GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE
   361  GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLLADS TDGMASVAAY
   421  TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL YETVPVVDGS PILRDLLFSP DHRHIYLLSE
   481  KQVSQLPVET CEQYQSCAAC LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV
   541  QVRVRPNNVS VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ
   601  ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS PYPCHWCKYR
   661  HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ PLTLRAKNLP QPQSGQKNYE
   721  CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR
   781  ALLYKCWAQR PSCGLCLKAD PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP
   841  RITQIHPLVG PKEGGTRVTI VGENLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE
   901  SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG TRLTISGSSL
   961  DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP ITLAIDRANI SSPGLIYTYT
  1021  QDPTVTRLEP TWSIINGSTA ITVSGTHLLT VQEPRVRAKY RGIETTNTCQ VINDTAMLCK
  1081  APGIFLGRPQ PRAQGEHPDE FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP
  1141  GSHVVLKGKN LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG
  1201  LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD RTLKRLQLQM
  1261  DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR TYAVRVLFPG IEAHPVLKEL
  1321  DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL EAQSSFSMRD RGTVASLTMV ALQSRLDYAT
  1381  GLLKQLLADL IEKNLESKNH PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY
  1441  CAIKQQMEKG PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC
  1501  DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT KIECDWKRLN
  1561  SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES LLRTASSPDS LRSRAPMITP
  1621  DQETGTKLWH LVKNHDHADH REGDRGSKMV SEIYLTRLLA TKGTLQKFVD DLFETVFSTA
  1681  HRGSALPLAI KYMFDFLDEQ ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK
  1741  NSITDACLSV VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS
  1801  ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS CRKHKLRQKL
  1861  EQIISLVSSD S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLXNA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

24 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLXNA3.

Disease | ImmuneIEDB

Conditions an epitope on PLXNA3 was assayed in.

• berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.38

gnomAD pLI

0.05

gnomAD missense Z

0.68

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon extension involved in axon guidance
• axon guidance
• branchiomotor neuron axon guidance
• facial nerve structural organization
• gonadotrophin-releasing hormone neuronal migration to the hypothalamus
• hippocampus development
• motor neuron axon guidance
• negative chemotaxis
• negative regulation of axon extension involved in axon guidance
• neuron projection guidance
• olfactory nerve formation
• positive regulation of cytoskeleton organization
• pyramidal neuron development
• regulation of cell migration
• semaphorin-plexin signaling pathway
• synapse assembly
• trigeminal nerve structural organization

Molecular functions

• semaphorin receptor activity

Cellular components

• plasma membrane
• semaphorin receptor complex

Protein domainsUniProt · Pfam · InterPro

• Sema domain
• Plexin repeat
• IPT domain
• Rho GTPase activation protein
• Plexin, cytoplasmic RasGAP domain
• Immunoglobulin-like fold
• Immunoglobulin E-set
• WD40/YVTN repeat-like-containing domain superfamily
• PSI domain
• Plexin family
• Sema domain superfamily
• Plexin, TIG domain 1
• Plexin, TIG domain 2
• Plexin, cytoplasmic RhoGTPase-binding domain
• Sema domain
• Plexin repeat
• IPT/TIG domain
• Plexin cytoplasmic RasGAP domain
• TIG domain
• TIG domain found in plexin
• Plexin cytoplasmic RhoGTPase-binding domain
• Plexin A/B, PSI domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PLXNA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CBFA2T3
• MICAL1