PLXND1

Protein identityUniProt · HPA

UniProt accession

Q9Y4D7

Gene

PLXND1

Ensembl

ENSG00000004399

Chromosome

3

Canonical length

1925 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of axonogenesis; semaphorin-plexin signaling pathway; and synapse assembly. Predicted to act upstream of or within circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and kidney development. Located in lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1925 residues, UniProt reviewed canonical sequence.

>Q9Y4D7|PLXND1
     1  MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ RRFPSPTPTN
    61  NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD SPLCHAPQLP QASCEHPRRL
   121  TDNYNKILQL DPGQGLVVVC GSIYQGFCQL RRRGNISAVA VRFPPAAPPA EPVTVFPSML
   181  NVAANHPNAS TVGLVLPPAA GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI
   241  RSLDTRGDLA KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA
   301  LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG RGDLYSRLVS
   361  VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI RAARTACFVE PAPDVVAVLD
   421  SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL QHPLSILQPL KATPVFRAPG LTSVAVASVN
   481  NYTAVFLGTV NGRLLKINLN ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ
   541  MARVKVAACN VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC
   601  PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP GPAFGHQIAY
   661  CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY DCSRTAQVYP HTACTSCLSA
   721  QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ DCPRTLLSPL APVPTGGSQN ILVPLANTAF
   781  FQGAALECSF GLEEIFEAVW VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE
   841  PMTVMVYNCA MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS
   901  GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV TGPAPGPLSG
   961  VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT IHGNDLHVGS ELQVLVNDTD
  1021  PCTELMRTDT SIACTMPEGA LPAPVPVCVR FERRGCVHGN LTFWYMQNPV ITAISPRRSP
  1081  VSGGRTITVA GERFHMVQNV SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF
  1141  INGRAYADEV AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH
  1201  KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT IQVGNFNQTI
  1261  ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE
  1321  EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSQTLNS
  1381  QGSSQAQETH PLLGEWKIPE SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD
  1441  RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI
  1501  CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN IEAKPRNLNV
  1561  SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYIL
  1621  RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT
  1681  DELAEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF
  1741  FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ
  1801  AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE QEMNAHLAEE
  1861  SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMEDNIYE
  1921  CYSEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLXND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

105 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLXND1.

Disease | AllUniProt

Conditions PLXND1 is implicated in, by any mechanism.

• Congenital heart defects, multiple types, 9 (CHTD9) MIM:620294

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 470 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital heart defects, multiple types, 9

Disease | AutoantibodyPubMed

Conditions in which antibodies against PLXND1 are reported. Each links to that disease's full target list.

Showing 0 of 2 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for PLXND1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.16

gnomAD pLI

1

gnomAD missense Z

3.35

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• aorta development
• branching involved in blood vessel morphogenesis
• cardiac septum development
• coronary vasculature development
• dichotomous subdivision of terminal units involved in salivary gland branching
• endothelial cell migration
• kidney development
• negative regulation of cell adhesion
• negative regulation of neuron apoptotic process
• outflow tract morphogenesis
• positive regulation of axonogenesis
• regulation of angiogenesis
• regulation of cell migration
• regulation of cell shape
• semaphorin-plexin signaling pathway
• synapse assembly
• synaptic target recognition

Molecular functions

• protein domain specific binding
• semaphorin receptor activity

Cellular components

• axon
• cell body
• glutamatergic synapse
• lamellipodium
• lamellipodium membrane
• plasma membrane
• semaphorin receptor complex

Protein domainsUniProt · Pfam · InterPro

• Sema domain
• Plexin repeat
• IPT domain
• Rho GTPase activation protein
• Plexin, cytoplasmic RasGAP domain
• Immunoglobulin-like fold
• Immunoglobulin E-set
• WD40/YVTN repeat-like-containing domain superfamily
• PSI domain
• Plexin family
• Sema domain superfamily
• Plexin, TIG domain 1
• Plexin, cytoplasmic RhoGTPase-binding domain
• Sema domain
• Plexin repeat
• IPT/TIG domain
• Plexin cytoplasmic RasGAP domain
• TIG domain
• Plexin cytoplasmic RhoGTPase-binding domain
• Plexin-D1, sema domain

KeywordsUniProt

• Angiogenesis
• Cell membrane
• Cell projection
• Developmental protein
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PLXND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NRP1
• SEMA4A
• SH3BP1
• SEMA3A
• SEMA3C
• SEMA3E