Seroatlas · Human Serome Atlas

SEMA3C

Semaphorin-3C

Also known as: SEM3C_HUMAN, SEMAE, SemE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99985
Gene
SEMA3C
Ensembl
ENSG00000075223
Chromosome
7
Canonical length
751 aa
Protein class
Predicted secreted proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

751 residues, UniProt reviewed canonical sequence.

>Q99985|SEMA3C
     1  MAFRTICVLV GVFICSICVK GSSQPQARVY LTFDELRETK TSEYFSLSHH PLDYRILLMD
    61  EDQDRIYVGS KDHILSLNIN NISQEALSVF WPASTIKVEE CKMAGKDPTH GCGNFVRVIQ
   121  TFNRTHLYVC GSGAFSPVCT YLNRGRRSED QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN
   181  EELFSGMYID FMGTDAAIFR SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV
   241  YFFFKEKLTD NNRSTKQIHS MIARICPNDT GGLRSLVNKW TTFLKARLVC SVTDEDGPET
   301  HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN GPFAHKEGPN
   361  HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KEFPDDVVTF IRNHPLMYNS IYPIHKRPLI
   421  VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG TDRGTVQKVV VLPTNNSVSG ELILEELEVF
   481  KNHAPITTMK ISSKKQQLYV SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS
   541  RFYPTGKRRS RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVKNNTTFL ECAPKSPQAS
   601  IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQGSDQGL YHCIATENSF KQTIAKINFK
   661  VLDSEMVAVV TDKWSPWTWA SSVRALPFHP KDIMGAFSHS EMQMINQYCK DTRQQHQQGD
   721  ESQKMRGDYG KLKALINSRK SRNRRNQLPE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEMA3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 65 nTPM
  • prostate: 63 nTPM
  • breast: 54 nTPM
  • ovary: 52 nTPM
  • adipose tissue: 50 nTPM
  • cervix: 50 nTPM

Single-cell type

  • mesothelial cells: 1,101 nCPM
  • respiratory ionocytes: 1,008 nCPM
  • urothelial cells: 931 nCPM
  • schwann cells: 893 nCPM
  • epididymal basal cells: 742 nCPM
  • melanocytes: 720 nCPM

Immune cell

  • basophil: 50 nTPM
  • classical monocyte: 5.8 nTPM
  • myeloid DC: 3.6 nTPM
  • plasmacytoid DC: 3.3 nTPM
  • neutrophil: 2.6 nTPM
  • intermediate monocyte: 2.4 nTPM

Brain region

  • pons: 42 nTPM
  • hypothalamus: 33 nTPM
  • white matter: 31 nTPM
  • medulla oblongata: 28 nTPM
  • cerebral cortex: 28 nTPM
  • spinal cord: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
0.99
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEMA3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEMA3C as an antibody target. Whether an autoantibody or antibody against SEMA3C could matter depends on whether native SEMA3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEMA3C is annotated as secreted, so native SEMA3C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SEMA3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEMA3C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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