Seroatlas · Human Serome Atlas

SEMA4F

Semaphorin-4F

Also known as: SEM4F_HUMAN, SEMAM, SEMAW

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95754
Gene: SEMA4F
Ensembl: ENSG00000135622
Chromosome: 2
Canonical length: 770 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>O95754|SEMA4F
     1  MPASAARPRP GPGQPTASPF PLLLLAVLSG PVSGRVPRSV PRTSLPISEA DSCLTRFAVP
    61  HTYNYSVLLV DPASHTLYVG ARDTIFALSL PFSGERPRRI DWMVPEAHRQ NCRKKGKKED
   121  ECHNFVQILA IANASHLLTC GTFAFDPKCG VIDVSRFQQV ERLESGRGKC PFEPAQRSAA
   181  VMAGGVLYAA TVKNYLGTEP IITRAVGRAE DWIRTDTLPS WLNAPAFVAA VALSPAEWGD
   241  EDGDDEIYFF FTETSRAFDS YERIKVPRVA RVCAGDLGGR KTLQQRWTTF LKADLLCPGP
   301  EHGRASSVLQ DVAVLRPELG AGTPIFYGIF SSQWEGATIS AVCAFRPQDI RTVLNGPFRE
   361  LKHDCNRGLP VVDNDVPQPR PGECITNNMK LRHFGSSLSL PDRVLTFIRD HPLMDRPVFP
   421  ADGHPLLVTT DTAYLRVVAH RVTSLSGKEY DVLYLGTEDG HLHRAVRIGA QLSVLEDLAL
   481  FPEPQPVENM KLYHSWLLVG SRTEVTQVNT TNCGRLQSCS ECILAQDPVC AWSFRLDECV
   541  AHAGEHRGLV QDIESADVSS LCPKEPGERP VVFEVPVATA AHVVLPCSPS SAWASCVWHQ
   601  PSGVTALTPR RDGLEVVVTP GAMGAYACEC QEGGAAHVVA AYSLVWGSQR DAPSRAHTVG
   661  AGLAGFFLGI LAASLTLILI GRRQQRRRQR ELLARDKVGL DLGAPPSGTT SYSQDPPSPS
   721  PEDERLPLAL AKRGSGFGGF SPPFLLDPCP SPAHIRLTGA PLATCDETSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEMA4F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 6.6 nTPM
cerebellum: 5.4 nTPM
hypothalamus: 5.4 nTPM
pituitary gland: 4.4 nTPM
retina: 4.3 nTPM
hippocampal formation: 3.8 nTPM

Single-cell type

brain excitatory neurons: 25 nCPM
other brain neurons: 23 nCPM
brain inhibitory neurons: 19 nCPM
gonadotrophs: 19 nCPM
early primary spermatocytes: 13 nCPM
retinal amacrine cells: 13 nCPM

Immune cell

gdT-cell: 1.9 nTPM
memory CD8 T-cell: 1.7 nTPM
naive CD8 T-cell: 1.3 nTPM
MAIT T-cell: 1.2 nTPM
memory B-cell: 1.1 nTPM
memory CD4 T-cell: 1.1 nTPM

Brain region

hypothalamus: 26 nTPM
hippocampal formation: 26 nTPM
cerebral cortex: 26 nTPM
basal ganglia: 23 nTPM
amygdala: 19 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sema domain
Plexin repeat
WD40/YVTN repeat-like-containing domain superfamily
PSI domain
Semaphorin
Sema domain superfamily
Sema domain
Plexin repeat
Semaphorin 4F, C-terminal domain
Semaphorin 4F, Sema domain
Semaphorin 4F C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEMA4F as an antibody target. Whether an autoantibody or antibody against SEMA4F could matter depends on whether native SEMA4F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEMA4F is annotated at the cell surface, where native SEMA4F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SEMA4F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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