Seroatlas · Human Serome Atlas

PLXDC2

Plexin domain-containing protein 2

Also known as: FLJ14623, PXDC2_HUMAN, TEM7R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX71
Gene: PLXDC2
Ensembl: ENSG00000120594
Chromosome: 10
Canonical length: 529 aa
Protein class: Predicted membrane proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q6UX71|PLXDC2
     1  MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT EEEVEVDSHA
    61  YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG QDNNTQIEED TDHNYYISRI
   121  YGPSDSASRD LWVNIDQMEK DKVKIHGILS NTHRQAARVN LSFDFPFYGH FLREITVATG
   181  GFIYTGEVVH RMLTATQYIA PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL
   241  GSFTFQATLL MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
   301  IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS KLQRCSSGFD
   361  RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT TQFRVLTTTR RAVTSQFPTS
   421  LPTEDDTKIA LHLKDNGAST DDSAAEKKGG TLHAGLIIGI LILVLIVATA ILVTVYMYHH
   481  PTSAASIFFI ERRPSRWPAM KFRRGSGHPA YAEVEPVGEK EGFIVSEQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLXDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 29 nTPM
retina: 17 nTPM
gallbladder: 16 nTPM
lung: 16 nTPM
skin: 16 nTPM
parathyroid gland: 15 nTPM

Single-cell type

microglia: 7,582 nCPM
neutrophils: 2,495 nCPM
macrophages: 1,941 nCPM
monocytes: 1,654 nCPM
fibro-adipogenic progenitors: 1,609 nCPM
megakaryocyte progenitors: 1,608 nCPM

Immune cell

neutrophil: 82 nTPM
classical monocyte: 58 nTPM
non-classical monocyte: 38 nTPM
myeloid DC: 36 nTPM
intermediate monocyte: 33 nTPM
total PBMC: 18 nTPM

Brain region

white matter: 79 nTPM
hypothalamus: 71 nTPM
thalamus: 64 nTPM
medulla oblongata: 57 nTPM
midbrain: 54 nTPM
choroid plexus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.13
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLXDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTTN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLXDC2 as an antibody target. Whether an autoantibody or antibody against PLXDC2 could matter depends on whether native PLXDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLXDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLXDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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