Seroatlas · Human Serome Atlas

MAP1LC3C

Microtubule-associated protein 1 light chain 3 gamma

Also known as: ATG8J, MLP3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXW4
Gene: MAP1LC3C
Ensembl: ENSG00000197769
Chromosome: 1
Canonical length: 147 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytoplasmic bodies

OverviewNCBI Gene

Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q9BXW4|MAP1LC3C
     1  MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL PPLDKTKFLV
    61  PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT MAEIYRDYKD EDGFVYMTYA
   121  SQETFGCLES AAPRDGSSLE DRPCNPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP1LC3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

breast: 13 nTPM
adipose tissue: 13 nTPM
placenta: 10 nTPM
salivary gland: 6.9 nTPM
lung: 5.6 nTPM
skin: 5.4 nTPM

Single-cell type

fibroblasts: 3.7 nCPM
kupffer cells: 3.1 nCPM
fibro-adipogenic progenitors: 2 nCPM
early primary spermatocytes: 1.6 nCPM
ovarian stromal cells: 1.4 nCPM
adipocytes: 1.2 nCPM

Immune cell

non-classical monocyte: 0.6 nTPM
basophil: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebral cortex: 4 nTPM
choroid plexus: 1.8 nTPM
hypothalamus: 1.7 nTPM
pons: 1.6 nTPM
basal ganglia: 1.5 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Autophagy protein Atg8 ubiquitin-like
Ubiquitin-like domain superfamily
Autophagy protein Atg8 ubiquitin like
Microtubule-associated protein 1A/1B light chain 3C

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP1LC3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP1LC3C as an antibody target. Whether an autoantibody or antibody against MAP1LC3C could matter depends on whether native MAP1LC3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP1LC3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP1LC3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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