Seroatlas · Human Serome Atlas

MAP1LC3A

Microtubule-associated protein 1 light chain 3 alpha

Also known as: ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, MLP3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H492
Gene
MAP1LC3A
Ensembl
ENSG00000101460
Chromosome
20
Canonical length
121 aa
Protein class
Predicted intracellular proteins
Subcellular location
Primary cilium,Centriolar satellite

OverviewNCBI Gene

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>Q9H492|MAP1LC3A
     1  MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM
    61  SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG
   121  F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP1LC3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
222 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 222 nTPM
  • cerebral cortex: 218 nTPM
  • midbrain: 197 nTPM
  • hippocampal formation: 193 nTPM
  • cerebellum: 190 nTPM
  • amygdala: 190 nTPM

Single-cell type

  • late spermatids: 1,114 nCPM
  • syncytiotrophoblasts: 319 nCPM
  • esophageal apical cells: 295 nCPM
  • decidual stromal cells: 228 nCPM
  • hepatic stellate cells: 168 nCPM
  • early spermatids: 152 nCPM

Immune cell

  • neutrophil: 86 nTPM
  • T-reg: 12 nTPM
  • eosinophil: 11 nTPM
  • memory B-cell: 9.4 nTPM
  • naive B-cell: 6.1 nTPM
  • memory CD4 T-cell: 5.5 nTPM

Brain region

  • pons: 266 nTPM
  • hypothalamus: 247 nTPM
  • medulla oblongata: 223 nTPM
  • midbrain: 221 nTPM
  • cerebral cortex: 203 nTPM
  • hippocampal formation: 189 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.33
gnomAD pLI
0.03
gnomAD missense Z
1.46
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP1LC3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP1LC3A as an antibody target. Whether an autoantibody or antibody against MAP1LC3A could matter depends on whether native MAP1LC3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP1LC3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP1LC3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAP1LC3A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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