EID1
EP300-interacting inhibitor of differentiation 1
Also known as: C15orf3, CRI1, EID-1, EID1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y6B2
- Gene
- EID1
- Ensembl
- ENSG00000255302
- Chromosome
- 15
- Canonical length
- 187 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables histone acetyltransferase binding activity. Involved in cell differentiation and negative regulation of DNA-templated transcription. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasmic ribonucleoprotein granule and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
187 residues, UniProt reviewed canonical sequence.
>Q9Y6B2|EID1
1 MSEMAELSEL YEESSDLQMD VMPGEGDLPQ MEVGSGSREL SLRPSRSGAQ QLEEEGPMEE
61 EEAQPMAAPE GKRSLANGPN AGEQPGQVAG ADFESEDEGE EFDDWEDDYD YPEEEQLSGA
121 GYRVSAALEE ADKMFLRTRE PALDGGFQMH YEKTPFDQLA FIEELFSLMV VNRLTEELGC
181 DEIIDRELocalizationUniProt · AlphaFold · HPA
Whether an antibody against EID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 262 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 262 nTPM
- skeletal muscle: 261 nTPM
- blood vessel: 234 nTPM
- tongue: 213 nTPM
- cerebral cortex: 197 nTPM
- adrenal gland: 195 nTPM
Single-cell type
- decidual stromal cells: 735 nCPM
- smooth muscle cells: 719 nCPM
- melanocytes: 568 nCPM
- peritubular myoid cells: 565 nCPM
- müller glia: 565 nCPM
- leydig cells: 504 nCPM
Immune cell
- total PBMC: 441 nTPM
- myeloid DC: 359 nTPM
- plasmacytoid DC: 356 nTPM
- basophil: 347 nTPM
- T-reg: 333 nTPM
- classical monocyte: 313 nTPM
Brain region
- cerebral cortex: 179 nTPM
- white matter: 142 nTPM
- hypothalamus: 122 nTPM
- choroid plexus: 113 nTPM
- basal ganglia: 103 nTPM
- midbrain: 102 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0.43
- gnomAD missense Z
- -0.14
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of EID1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EID1 as an antibody target. Whether an autoantibody or antibody against EID1 could matter depends on whether native EID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EID1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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