Seroatlas · Human Serome Atlas

GNPDA2

Glucosamine-6-phosphate deaminase 2

Also known as: GNPI2_HUMAN, SB52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDQ7
Gene
GNPDA2
Ensembl
ENSG00000163281
Chromosome
4
Canonical length
276 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles
Quaternary structure
Homohexamer

OverviewNCBI Gene

The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q8TDQ7|GNPDA2
     1  MRLVILDNYD LASEWAAKYI CNRIIQFKPG QDRYFTLGLP TGSTPLGCYK KLIEYHKNGH
    61  LSFKYVKTFN MDEYVGLPRN HPESYHSYMW NNFFKHIDID PNNAHILDGN AADLQAECDA
   121  FENKIKEAGG IDLFVGGIGP DGHIAFNEPG SSLVSRTRLK TLAMDTILAN AKYFDGDLSK
   181  VPTMALTVGV GTVMDAREVM ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTIFVCD
   241  EDATLELRVK TVKYFKGLMH VHNKLVDPLF SMKDGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNPDA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 21 nTPM
  • cerebellum: 20 nTPM
  • retina: 17 nTPM
  • thyroid gland: 17 nTPM
  • heart muscle: 16 nTPM
  • endometrium: 15 nTPM

Single-cell type

  • oocytes: 235 nCPM
  • cardiomyocytes: 131 nCPM
  • epicardial cells: 86 nCPM
  • adipocytes: 51 nCPM
  • early primary spermatocytes: 43 nCPM
  • brain excitatory neurons: 43 nCPM

Immune cell

  • memory B-cell: 12 nTPM
  • naive CD4 T-cell: 11 nTPM
  • MAIT T-cell: 11 nTPM
  • naive CD8 T-cell: 11 nTPM
  • T-reg: 11 nTPM
  • naive B-cell: 11 nTPM

Brain region

  • cerebellum: 45 nTPM
  • cerebral cortex: 26 nTPM
  • white matter: 26 nTPM
  • basal ganglia: 22 nTPM
  • spinal cord: 21 nTPM
  • hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.01
gnomAD missense Z
1.09
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNPDA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNPDA2 as an antibody target. Whether an autoantibody or antibody against GNPDA2 could matter depends on whether native GNPDA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNPDA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GNPDA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNPDA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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