Seroatlas · Human Serome Atlas

NDEL1

Nuclear distribution protein nudE-like 1

Also known as: MITAP1, NDE1L1, NDE2, NDEL1_HUMAN, NUDEL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZM8
Gene: NDEL1
Ensembl: ENSG00000166579
Chromosome: 17
Canonical length: 345 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Involved in chromosome segregation; positive regulation of GTPase activity; and regulation of intracellular protein transport. Located in kinetochore. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9GZM8|NDEL1
     1  MDGEDIPDFS SLKEETAYWK ELSLKYKQSF QEARDELVEF QEGSRELEAE LEAQLVQAEQ
    61  RNRDLQADNQ RLKYEVEALK EKLEHQYAQS YKQVSVLEDD LSQTRAIKEQ LHKYVRELEQ
   121  ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE
   181  LAVRERQQEV TRKSAPSSPT LDCEKMDSAV QASLSLPATP VGKGTENTFP SPKAIPNGFG
   241  TSPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYISGN VNCGVLNGNG
   301  TKFSRSGHTS FFDKGAVNGF DPAPPPPGLG SSRPSSAPGM LPLSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 103 nTPM
skin: 88 nTPM
blood vessel: 60 nTPM
adrenal gland: 57 nTPM
esophagus: 53 nTPM
cerebral cortex: 47 nTPM

Single-cell type

neutrophils: 1,302 nCPM
mast cells: 515 nCPM
endometrial luminal cells: 454 nCPM
pituicytes/fscs: 406 nCPM
epicardial cells: 403 nCPM
esophageal apical cells: 334 nCPM

Immune cell

neutrophil: 176 nTPM
eosinophil: 99 nTPM
basophil: 86 nTPM
MAIT T-cell: 37 nTPM
T-reg: 37 nTPM
total PBMC: 36 nTPM

Brain region

cerebral cortex: 70 nTPM
basal ganglia: 64 nTPM
white matter: 64 nTPM
pons: 61 nTPM
hypothalamus: 61 nTPM
thalamus: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDEL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDEL1 as an antibody target. Whether an autoantibody or antibody against NDEL1 could matter depends on whether native NDEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDEL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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