Seroatlas · Human Serome Atlas

GSE1

Genetic suppressor element 1

Also known as: GSE1_HUMAN, KIAA0182

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14687
Gene: GSE1
Ensembl: ENSG00000131149
Chromosome: 16
Canonical length: 1217 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been observed in breast cancer patients. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1217 residues, UniProt reviewed canonical sequence.

>Q14687|GSE1
     1  MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL SAQAAPSSSF
    61  AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP KRVPMGPIIV PPGGHSVPST
   121  PPVVTIAPTK TVNGVWRSES RQDAGSRSSS GGRERLIVEP PLPQEKAGGP AIPSHLLSTP
   181  YPFGLSPSSV VQDSRFPPLN LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG
   241  LDPATAAAYY HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH
   301  LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE READREREKE
   361  REREREKERE QEKEREREKE RERELERQRE QRAREKELLA AKALEPSFLP VAELHGLRGH
   421  ATEERGKPSE QLTPTRAEKL KDAGLQAPKP VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS
   481  SAATALLIQR TNEEEKWLAR QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH
   541  RPESTTRPGP NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA
   601  ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ PPPPPPREGG
   661  SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG ELSGPLKPGS PYRPPVPRAP
   721  DPAYIYDEFL QQRRRLVSKL DLEERRRREA QEKGYYYDLD DSYDESDEEE VRAHLRCVAE
   781  QPPLKLDTSS EKLEFLQLFG LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS
   841  PRLALSTRYS PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA
   901  AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG KLEQVRPQEL
   961  SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI PVPLSHSTNG KSKPWEPFVA
  1021  EEFAHQFHES VLQSTQKALQ KHKGSVAVLS AEQNHKVDTS VHYNIPELQS SSRAPPPQHN
  1081  GQQEPPTARK GPPTQELDRD SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ
  1141  NLERQVLQTQ CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL
  1201  ALPAMHWPRG YLKGYPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

thymus: 38 nTPM
parathyroid gland: 36 nTPM
skeletal muscle: 36 nTPM
bone marrow: 30 nTPM
placenta: 30 nTPM
salivary gland: 29 nTPM

Single-cell type

adipocytes: 683 nCPM
somatotrophs: 615 nCPM
syncytiotrophoblasts: 574 nCPM
sertoli cells: 520 nCPM
corticotrophs: 433 nCPM
lactotrophs: 393 nCPM

Immune cell

non-classical monocyte: 3.4 nTPM
basophil: 2.9 nTPM
eosinophil: 2.2 nTPM
memory B-cell: 1.6 nTPM
naive B-cell: 1.5 nTPM
gdT-cell: 1.4 nTPM

Brain region

cerebellum: 95 nTPM
cerebral cortex: 60 nTPM
midbrain: 57 nTPM
medulla oblongata: 50 nTPM
pons: 48 nTPM
hypothalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: -3.31
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Genetic suppressor element-like
Genetic suppressor element 1
Protein of unknown function (DUF3736)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GSE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSE1 as an antibody target. Whether an autoantibody or antibody against GSE1 could matter depends on whether native GSE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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