Seroatlas · Human Serome Atlas

NDE1

Nuclear distribution protein nudE homolog 1

Also known as: FLJ20101, NDE, NDE1_HUMAN, nudE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NXR1
Gene
NDE1
Ensembl
ENSG00000072864
Chromosome
16
Canonical length
335 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q9NXR1|NDE1
     1  MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR
    61  NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA
   121  NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL
   181  AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST
   241  GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG
   301  GERRPSSTSV PLGDKGLDTS CRWLSKSTTR SSSSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 35 nTPM
  • skin: 29 nTPM
  • bone marrow: 24 nTPM
  • thymus: 22 nTPM
  • colon: 22 nTPM
  • vagina: 20 nTPM

Single-cell type

  • oligodendrocytes: 161 nCPM
  • ependymal cells: 64 nCPM
  • microglia: 40 nCPM
  • podocytes: 28 nCPM
  • choroid plexus epithelial cells: 27 nCPM
  • papillary tip epithelial cells: 24 nCPM

Immune cell

  • neutrophil: 22 nTPM
  • eosinophil: 15 nTPM
  • non-classical monocyte: 12 nTPM
  • NK-cell: 8.6 nTPM
  • basophil: 5.2 nTPM
  • classical monocyte: 4.7 nTPM

Brain region

  • white matter: 84 nTPM
  • medulla oblongata: 61 nTPM
  • pons: 51 nTPM
  • midbrain: 48 nTPM
  • basal ganglia: 46 nTPM
  • cerebellum: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDE1.

Disease | AllUniProt

Conditions NDE1 is implicated in, by any mechanism.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 262 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Lissencephaly 4
  • NDE1-related microhydranencephaly
  • NDE1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.01
gnomAD missense Z
-1.13
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDE1 as an antibody target. Whether an autoantibody or antibody against NDE1 could matter depends on whether native NDE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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