Seroatlas · Human Serome Atlas

TPCN1

Two pore channel protein 1

Also known as: FLJ20612, KIAA1169, TPC1, TPC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULQ1
Gene: TPCN1
Ensembl: ENSG00000186815
Chromosome: 12
Canonical length: 816 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

OverviewNCBI Gene

Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

816 residues, UniProt reviewed canonical sequence.

>Q9ULQ1|TPCN1
     1  MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP SLSSGGESSP
    61  SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY LFAHNHLFYL MELATALLLL
   121  LLSLCEAPAV PALRLGIYVH ATLELFALMV VVFELCMKLR WLGLHTFIRH KRTMVKTSVL
   181  VVQFVEAIVV LVRQMSHVRV TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL
   241  FFMIIFAILG FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF
   301  IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLI SQRRPAGISY
   361  RQFEGLMRFY KPRMSARERY LTFKALNQNN TPLLSLKDFY DIYEVAALKW KAKKNREHWF
   421  DELPRTALLI FKGINILVKS KAFQYFMYLV VAVNGVWILV ETFMLKGGNF FSKHVPWSYL
   481  VFLTIYGVEL FLKVAGLGPV EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP
   541  LQLLRLFKLK ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT
   601  STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY IIMEGVTSQT
   661  SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN QDSEVDGGIT LEKEISKEEL
   721  VAVLELYREA RGASSDVTRL LETLSQMERY QQHSMVFLGR RSRTKSDLSL KMYQEEIQEW
   781  YEEHAREQEQ QRQLSSSAAP AAQQPPGSRQ RSQTVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPCN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 107 nTPM
heart muscle: 65 nTPM
thyroid gland: 53 nTPM
pancreas: 50 nTPM
kidney: 48 nTPM
adrenal gland: 46 nTPM

Single-cell type

proximal tubule cells: 487 nCPM
renal collecting duct principal cells: 319 nCPM
urothelial cells: 305 nCPM
astrocytes: 304 nCPM
bergmann glia: 261 nCPM
papillary tip epithelial cells: 245 nCPM

Immune cell

classical monocyte: 15 nTPM
myeloid DC: 10 nTPM
NK-cell: 8.6 nTPM
basophil: 6.9 nTPM
naive B-cell: 5.2 nTPM
plasmacytoid DC: 5.1 nTPM

Brain region

cerebellum: 152 nTPM
basal ganglia: 119 nTPM
choroid plexus: 108 nTPM
midbrain: 107 nTPM
pons: 104 nTPM
thalamus: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0
gnomAD missense Z: 2.44
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ion transport domain
Voltage-dependent channel domain superfamily
Ion transport protein
Two pore channel protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPCN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPCN1 as an antibody target. Whether an autoantibody or antibody against TPCN1 could matter depends on whether native TPCN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPCN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPCN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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