Seroatlas · Human Serome Atlas

LSMEM2

Leucine-rich single-pass membrane protein 2

Also known as: C3orf45, FLJ38608, LSME2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N112
Gene: LSMEM2
Ensembl: ENSG00000179564
Chromosome: 3
Canonical length: 164 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q8N112|LSMEM2
     1  MPSLAPDCPL LAMPEETQED SVAPMMPSQR SRGPLAPNHV HEVCLHQVES ISDLHSGAGT
    61  LRPYLTEEAR PWDELLGVLP PSLCAQAGCS PVYRRGGFLL LLALLVLTCL VLALLAVYLS
   121  VLQSESLRIL AHTLRTQEET LLKLRLASLS QLRRLNSSEA QAPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSMEM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 22 nTPM
skeletal muscle: 15 nTPM
tongue: 5.1 nTPM
testis: 3.7 nTPM
basal ganglia: 2.1 nTPM
spinal cord: 1.8 nTPM

Single-cell type

late spermatids: 501 nCPM
endometrial secretory cells: 62 nCPM
early spermatids: 53 nCPM
endometrial luminal cells: 32 nCPM
endometrial glandular cells: 23 nCPM
cardiomyocytes: 20 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 8.8 nTPM
basal ganglia: 6.7 nTPM
cerebral cortex: 4.8 nTPM
medulla oblongata: 4.6 nTPM
midbrain: 4.6 nTPM
thalamus: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4714
Domain of unknown function (DUF4714)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSMEM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STX7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSMEM2 as an antibody target. Whether an autoantibody or antibody against LSMEM2 could matter depends on whether native LSMEM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSMEM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSMEM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...