Seroatlas · Human Serome Atlas

VPS11

Vacuolar protein sorting-associated protein 11 homolog

Also known as: VPS11_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H270
Gene
VPS11
Canonical length
941 aa
Protein class
Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for VPS11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>Q9H270|VPS11
     1  MAAYLQWRRF VFFDKELVKE PLSNDGAAPG ATPASGSAAS KFLCLPPGIT VCDSGRGSLV
    61  FGDMEGQIWF LPRSLQLTGF QAYKLRVTHL YQLKQHNILA SVGEDEEGIN PLVKIWNLEK
   121  RDGGNPLCTR IFPAIPGTEP TVVSCLTVHE NLNFMAIGFT DGSVTLNKGD ITRDRHSKTQ
   181  ILHKGNYPVT GLAFRQAGKT THLFVVTTEN VQSYIVSGKD YPRVELDTHG CGLRCSALSD
   241  PSQDLQFIVA GDECVYLYQP DERGPCFAFE GHKLIAHWFR GYLIIVSRDR KVSPKSEFTS
   301  RDSQSSDKQI LNIYDLCNKF IAYSTVFEDV VDVLAEWGSL YVLTRDGRVH ALQEKDTQTK
   361  LEMLFKKNLF EMAINLAKSQ HLDSDGLAQI FMQYGDHLYS KGNHDGAVQQ YIRTIGKLEP
   421  SYVIRKFLDA QRIHNLTAYL QTLHRQSLAN ADHTTLLLNC YTKLKDSSKL EEFIKKKSES
   481  EVHFDVETAI KVLRQAGYYS HALYLAENHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFEQ
   541  AESNMKRYGK ILMHHIPEQT TQLLKGLCTD YRPSLEGRSD REAPGCRANS EEFIPIFANN
   601  PRELKAFLEH MSEVQPDSPQ GIYDTLLELR LQNWAHEKDP QVKEKLHAEA ISLLKSGRFC
   661  DVFDKALVLC QMHDFQDGVL YLYEQGKLFQ QIMHYHMQHE QYRQVISVCE RHGEQDPSLW
   721  EQALSYFARK EEDCKEYVAA VLKHIENKNL MPPLLVVQTL AHNSTATLSV IRDYLVQKLQ
   781  KQSQQIAQDE LRVRRYREET TRIRQEIQEL KASPKIFQKT KCSICNSALE LPSVHFLCGH
   841  SFHQHCFESY SESDADCPTC LPENRKVMDM IRAQEQKRDL HDQFQHQLRC SNDSFSVIAD
   901  YFGRGVFNKL TLLTDPPTAR LTSSLEAGLQ RDLLMHSRRG T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 27 nTPM
  • cerebellum: 26 nTPM
  • cerebral cortex: 25 nTPM
  • adrenal gland: 25 nTPM
  • endometrium: 24 nTPM
  • urinary bladder: 23 nTPM

Single-cell type

  • oligodendrocytes: 16 nCPM
  • brain excitatory neurons: 14 nCPM
  • brain inhibitory neurons: 14 nCPM
  • other brain neurons: 13 nCPM
  • renal collecting duct intercalated cells: 12 nCPM
  • microglia: 12 nCPM

Immune cell

  • basophil: 21 nTPM
  • myeloid DC: 21 nTPM
  • non-classical monocyte: 19 nTPM
  • classical monocyte: 17 nTPM
  • MAIT T-cell: 17 nTPM
  • naive CD8 T-cell: 17 nTPM

Brain region

  • white matter: 25 nTPM
  • hypothalamus: 25 nTPM
  • midbrain: 25 nTPM
  • cerebral cortex: 24 nTPM
  • pons: 24 nTPM
  • thalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VPS11.

Disease | AllUniProt

Conditions VPS11 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 587 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0
gnomAD missense Z
2.3

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS11 as an antibody target. Whether an autoantibody or antibody against VPS11 could matter depends on whether native VPS11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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