Seroatlas · Human Serome Atlas

MN1

Transcriptional activator MN1

Also known as: MGCR, MGCR1, MGCR1-PEN, MN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q10571
Gene: MN1
Ensembl: ENSG00000169184
Chromosome: 22
Canonical length: 1320 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1320 residues, UniProt reviewed canonical sequence.

>Q10571|MN1
     1  MFGLDQFEPQ VNSRNAGQGE RNFNETGLSM NTHFKAPAFH TGGPPGPVDP AMSALGEPPI
    61  LGMNMEPYGF HARGHSELHA GGLQAQPVHG FFGGQQPHHG HPGSHHPHQH HPHFGGNFGG
   121  PDPGASCLHG GRLLGYGGAA GGLGSQPPFA EGYEHMAESQ GPESFGPQRP GNLPDFHSSG
   181  ASSHAVPAPC LPLDQSPNRA ASFHGLPSSS GSDSHSLEPR RVTNQGAVDS LEYNYPGEAP
   241  SGHFDMFSPS DSEGQLPHYA AGRQVPGGAF PGASAMPRAA GMVGLSKMHA QPPQQQPQQQ
   301  QQPQQQQQQH GVFFERFSGA RKMPVGLEPS VGSRHPLMQP PQQAPPPPQQ QPPQQPPQQQ
   361  PPPPPGLLVR QNSCPPALPR PQQGEAGTPS GGLQDGGPML PSQHAQFEYP IHRLENRSMH
   421  PYSEPVFSMQ HPPPQQAPNQ RLQHFDAPPY MNVAKRPRFD FPGSAGVDRC ASWNGSMHNG
   481  ALDNHLSPSA YPGLPGEFTP PVPDSFPSGP PLQHPAPDHQ SLQQQQQQQQ QQQQQQQQQQ
   541  QQQQQQQQQQ RQNAALMIKQ MASRNQQQRL RQPNLAQLGH PGDVGQGGLV HGGPVGGLAQ
   601  PNFEREGGST GAGRLGTFEQ QAPHLAQESA WFSGPHPPPG DLLPRRMGGS GLPADCGPHD
   661  PSLAPPPPPG GSGVLFRGPL QEPMRMPGEG HVPALPSPGL QFGGSLGGLG QLQSPGAGVG
   721  LPSAASERRP PPPDFATSAL GGQPGFPFGA AGRQSTPHSG PGVNSPPSAG GGGGSSGGGG
   781  GGGAYPPQPD FQPSQRTSAS KLGALSLGSF NKPSSKDNLF GQSCLAALST ACQNMIASLG
   841  APNLNVTFNK KNPPEGKRKL SQNETDGAAV AGNPGSDYFP GGTAPGAPGP GGPSGTSSSG
   901  SKASGPPNPP AQGDGTSLSP NYTLESTSGN DGKPVSGGGG RGRGRRKRDS GHVSPGTFFD
   961  KYSAAPDSGG APGVSPGQQQ ASGAAVGGSS AGETRGAPTP HEKALTSPSW GKGAELLLGD
  1021  QPDLIGSLDG GAKSDSSSPN VGEFASDEVS TSYANEDEVS SSSDNPQALV KASRSPLVTG
  1081  SPKLPPRGVG AGEHGPKAPP PALGLGIMSN STSTPDSYGG GGGPGHPGTP GLEQVRTPTS
  1141  SSGAPPPDEI HPLEILQAQI QLQRQQFSIS EDQPLGLKGG KKGECAVGAS GAQNGDSELG
  1201  SCCSEAVKSA MSTIDLDSLM AEHSAAWYMP ADKALVDSAD DDKTLAPWEK AKPQNPNSKE
  1261  AHDLPANKAS ASQPGSHLQC LSVHCTDDVG DAKARASVPT WRSLHSDISN RFGTFVAALT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 47 nTPM
blood vessel: 22 nTPM
basal ganglia: 15 nTPM
ovary: 8.7 nTPM
tongue: 7 nTPM
heart muscle: 6.3 nTPM

Single-cell type

myonuclei: 254 nCPM
retinal amacrine cells: 133 nCPM
epicardial cells: 116 nCPM
pituitary stem cells: 108 nCPM
early spermatids: 70 nCPM
late spermatids: 64 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 45 nTPM
midbrain: 29 nTPM
thalamus: 20 nTPM
pons: 17 nTPM
cerebellum: 16 nTPM
cerebral cortex: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MN1.

Disease | AllUniProt

Conditions MN1 is implicated in, by any mechanism.

CEBALID syndrome (CEBALID) MIM:618774

Disease | GeneticClinVar

30 pathogenic / likely-pathogenic of 489 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

CEBALID syndrome
MN1 C-terminal truncation (MCTT) syndrome
Inborn genetic diseases
Thyroid cancer, nonmedullary, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 2.16
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Transcriptional activator MN1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MN1 as an antibody target. Whether an autoantibody or antibody against MN1 could matter depends on whether native MN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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