USP26

Protein identityUniProt · HPA

UniProt accession

Q9BXU7

Gene

USP26

Ensembl

ENSG00000134588

Chromosome

X

Canonical length

913 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

913 residues, UniProt reviewed canonical sequence.

>Q9BXU7|USP26
     1  MAALFLRGFV QIGNCKTGIS KSKEAFIEAV ERKKKDRLVL YFKSGKYSTF RLSDNIQNVV
    61  LKSYRGNQNH LHLTLQNNNG LFIEGLSSTD AEQLKIFLDR VHQNEVQPPV RPGKGGSVFS
   121  STTQKEINKT SFHKVDEKSS SKSFEIAKGS GTGVLQRMPL LTSKLTLTCG ELSENQHKKR
   181  KRMLSSSSEM NEEFLKENNS VEYKKSKADC SRCVSYNREK QLKLKELEEN KKLECESSCI
   241  MNATGNPYLD DIGLLQALTE KMVLVFLLQQ GYSDGYTKWD KLKLFFELFP EKICHGLPNL
   301  GNTCYMNAVL QSLLSIPSFA DDLLNQSFPW GKIPLNALTM CLARLLFFKD TYNIEIKEML
   361  LLNLKKAISA AAEIFHGNAQ NDAHEFLAHC LDQLKDNMEK LNTIWKPKSE FGEDNFPKQV
   421  FADDPDTSGF SCPVITNFEL ELLHSIACKA CGQVILKTEL NNYLSINLPQ RIKAHPSSIQ
   481  STFDLFFGAE ELEYKCAKCE HKTSVGVHSF SRLPRILIVH LKRYSLNEFC ALKKNDQEVI
   541  ISKYLKVSSH CNEGTRPPLP LSEDGEITDF QLLKVIRKMT SGNISVSWPA TKESKDILAP
   601  HIGSDKESEQ KKGQTVFKGA SRRQQQKYLG KNSKPNELES VYSGDRAFIE KEPLAHLMTY
   661  LEDTSLCQFH KAGGKPASSP GTPLSKVDFQ TVPENPKRKK YVKTSKFVAF DRIINPTKDL
   721  YEDKNIRIPE RFQKVSEQTQ QCDGMRICEQ APQQALPQSF PKPGTQGHTK NLLRPTKLNL
   781  QKSNRNSLLA LGSNKNPRNK DILDKIKSKA KETKRNDDKG DHTYRLISVV SHLGKTLKSG
   841  HYICDAYDFE KQIWFTYDDM RVLGIQEAQM QEDRRCTGYI FFYMHNEIFE EMLKREENAQ
   901  LNSKEVEETL QKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

0.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about USP26.

Disease | AllUniProt

Conditions USP26 is implicated in, by any mechanism.

• Spermatogenic failure, X-linked, 6 (SPGFX6) MIM:301101

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spermatogenic failure, X-linked, 6
• Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z

-0.08

DepMap mean gene effect

0.25

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G1/S transition of mitotic cell cycle
• negative regulation of proteasomal ubiquitin-dependent protein catabolic process
• protein deubiquitination
• proteolysis
• regulation of androgen receptor signaling pathway
• regulation of protein stability
• spermatogenesis

Molecular functions

• cysteine-type deubiquitinase activity
• deubiquitinase activity
• K48-linked deubiquitinase activity

Cellular components

• cytosol
• nucleoplasm
• nucleus
• sperm flagellum

Protein domainsUniProt · Pfam · InterPro

• Peptidase C19, ubiquitin carboxyl-terminal hydrolase
• Ubiquitin specific protease, conserved site
• Ubiquitin specific protease UPS, catalytic domain
• Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain
• Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain superfamily
• Papain-like cysteine peptidase superfamily
• Ubiquitin carboxyl-terminal hydrolases
• Ubiquitin carboxyl-terminal hydrolase
• N-terminal of ubiquitin carboxyl-terminal hydrolase 37

KeywordsUniProt

• Cell projection
• Cilium
• Cytoplasm
• Cytoskeleton
• Flagellum
• Hydrolase
• Nucleus
• Protease
• Thiol protease
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of USP26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RING1
• AR