Seroatlas · Human Serome Atlas

PXN

Paxillin

Also known as: PAXI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49023
Gene
PXN
Ensembl
ENSG00000089159
Chromosome
12
Canonical length
591 aa
Protein class
Predicted intracellular proteins
Subcellular location
Focal adhesion sites,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

591 residues, UniProt reviewed canonical sequence.

>P49023|PXN
     1  MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
    61  TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF
   121  PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL
   181  YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
   241  EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKIQG LEQRADGERC WAAGWPRDGG
   301  RSSPGGQDEG GFMAQGKTGS SSPPGGPPKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA
   361  CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH NLFSPRCYYC
   421  NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA
   481  RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK
   541  PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQNCFLKLF C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PXN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
118 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 118 nTPM
  • heart muscle: 85 nTPM
  • lung: 80 nTPM
  • adipose tissue: 79 nTPM
  • bone marrow: 77 nTPM
  • urinary bladder: 74 nTPM

Single-cell type

  • neutrophils: 539 nCPM
  • extravillous trophoblasts: 318 nCPM
  • rod photoreceptor cells: 198 nCPM
  • cone photoreceptor cells: 186 nCPM
  • urothelial cells: 161 nCPM
  • vascular endothelial cells: 160 nCPM

Immune cell

  • neutrophil: 170 nTPM
  • gdT-cell: 85 nTPM
  • total PBMC: 61 nTPM
  • memory CD8 T-cell: 56 nTPM
  • NK-cell: 52 nTPM
  • eosinophil: 49 nTPM

Brain region

  • thalamus: 56 nTPM
  • medulla oblongata: 56 nTPM
  • choroid plexus: 48 nTPM
  • spinal cord: 44 nTPM
  • midbrain: 41 nTPM
  • basal ganglia: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.08
gnomAD missense Z
1.57
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PXN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PXN as an antibody target. Whether an autoantibody or antibody against PXN could matter depends on whether native PXN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PXN is annotated at the cell surface, where native PXN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PXN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PXN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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