Seroatlas · Human Serome Atlas

PDCD10

Programmed cell death protein 10

Also known as: CCM3, PDC10_HUMAN, TFAR15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BUL8
Gene
PDCD10
Ensembl
ENSG00000114209
Chromosome
3
Canonical length
212 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>Q9BUL8|PDCD10
     1  MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK AEKENPGLTQ
    61  DIIMKILEKK SVEVNFTESL LRMAADDVEE YMIERPEPEF QDLNEKARAL KQILSKIPDE
   121  INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT
   181  YFKDGKAINV FVSANRLIHQ TNLILQTFKT VA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 58 nTPM
  • lymph node: 50 nTPM
  • tonsil: 49 nTPM
  • esophagus: 48 nTPM
  • colon: 48 nTPM
  • thymus: 47 nTPM

Single-cell type

  • platelets: 662 nCPM
  • esophageal apical cells: 490 nCPM
  • megakaryocytes: 414 nCPM
  • neutrophils: 198 nCPM
  • neutrophil progenitors: 193 nCPM
  • parietal cells: 186 nCPM

Immune cell

  • basophil: 226 nTPM
  • eosinophil: 197 nTPM
  • T-reg: 182 nTPM
  • neutrophil: 176 nTPM
  • non-classical monocyte: 140 nTPM
  • naive B-cell: 137 nTPM

Brain region

  • white matter: 46 nTPM
  • cerebral cortex: 43 nTPM
  • cerebellum: 39 nTPM
  • hypothalamus: 38 nTPM
  • spinal cord: 38 nTPM
  • medulla oblongata: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDCD10.

Disease | AllUniProt

Conditions PDCD10 is implicated in, by any mechanism.

  • Cerebral cavernous malformations 3 (CCM3) MIM:603285

Disease | GeneticClinVar

82 pathogenic / likely-pathogenic of 207 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.43
DepMap mean gene effect
0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD10 as an antibody target. Whether an autoantibody or antibody against PDCD10 could matter depends on whether native PDCD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD10 is annotated at the cell surface, where native PDCD10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDCD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDCD10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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