Seroatlas · Human Serome Atlas

SORBS1

Sorbin and SH3 domain-containing protein 1

Also known as: CAP, FLJ12406, KIAA1296, ponsin, SH3D5, sh3p12, SRBS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BX66
Gene: SORBS1
Ensembl: ENSG00000095637
Chromosome: 10
Canonical length: 1292 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Focal adhesion sites,Centrosome

OverviewNCBI Gene

This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

1292 residues, UniProt reviewed canonical sequence.

>Q9BX66|SORBS1
     1  MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA SGLVLPTDMD
    61  LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP GLEPEPSSAD EWRLSSSADA
   121  NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT SSSAAQPEVI VVPLYLVNTD RGQEGTARPP
   181  TPLGPLGCVP TIPATASAAS PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS
   241  FSPPPPLVPP APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA
   301  YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS PGKAIEKRAK
   361  DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK QIHKLNRDTP EENPYFPTYK
   421  FPELPEIQQT SEEDNPYTPT YQFPASTPSP KSEDDDSDLY SPRYSFSEDT KSPLSVPRSK
   481  SEMSYIDGEK VVKRSATLPL PARSSSLKSS SERNDWEPPD KKVDTRKYRA EPKSIYEYQP
   541  GKSSVLTNEK MSRDISPEEI DLKNEPWYKF FSELEFGKPP PKKIWDYTPG DCSILPREDR
   601  KTNLDKDLSL CQTELEADLE KMETLNKAPS ANVPQSSAIS PTPEISSETP GYIYSSNFHA
   661  VKRESDGAPG DLTSLENERQ IYKSVLEGGD IPLQGLSGLK RPSSSASTKD SESPRHFIPA
   721  DYLESTEEFI RRRHDDKEKL LADQRRLKRE QEEADIAARR HTGVIPTHHQ FITNERFGDL
   781  LNIDDTAKRK SGSEMRPARA KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG
   841  IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK GERITLLRQV
   901  DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA TASPQFSSHS
   961  KLITPAPSSL PHSRRALSPE MHAVTSEWIS LTVGVPGRRS LALTPPLPPL PEASIYNTDH
  1021  LALSPRASPS LSLSLPHLSW SDRPTPRSVA SPLALPSPHK TYSLAPTSQA SLHMNGDGGV
  1081  HTPSSGIHQD SFLQLPLGSS DSVISQLSDA FSSQSKRQPW REESGQYERK AERGAGERGP
  1141  GGPKISKKSC LKPSDVVRCL STEQRLSDLN TPEESRPGKP LGSAFPGSEA EQTERHRGGE
  1201  QAGRKAARRG GSQQPQAQQR RVTPDRSQTS QDLFSYQALY SYIPQNDDEL ELRDGDIVDV
  1261  MEKCDDGWFV GTSRRTKQFG TFPGNYVKPL YL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SORBS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 483 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 483 nTPM
colon: 421 nTPM
adipose tissue: 348 nTPM
heart muscle: 329 nTPM
urinary bladder: 328 nTPM
skeletal muscle: 246 nTPM

Single-cell type

smooth muscle cells: 2,332 nCPM
cardiomyocytes: 2,245 nCPM
adipocytes: 1,968 nCPM
myonuclei: 1,611 nCPM
bergmann glia: 1,572 nCPM
astrocytes: 1,465 nCPM

Immune cell

basophil: 6.1 nTPM
eosinophil: 1.2 nTPM
intermediate monocyte: 0.6 nTPM
MAIT T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
NK-cell: 0.4 nTPM

Brain region

hypothalamus: 362 nTPM
medulla oblongata: 358 nTPM
midbrain: 352 nTPM
basal ganglia: 324 nTPM
cerebral cortex: 314 nTPM
spinal cord: 303 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
SoHo domain
SH3-like domain superfamily
Endophilin/SH3RF
SH3 domain
Sorbin homologous domain
Variant SH3 domain
Variant SH3 domain
Sorbin and SH3 domain-containing protein 1, third SH3 domain
Sorbin and SH3 domain-containing protein 1, first SH3 domain
Sorbin and SH3 domain-containing protein 1, second SH3 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SORBS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SORBS1 as an antibody target. Whether an autoantibody or antibody against SORBS1 could matter depends on whether native SORBS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SORBS1 is annotated at the cell surface, where native SORBS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SORBS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...