Seroatlas · Human Serome Atlas

PARVB

Beta-parvin

Also known as: CGI-56, PARVB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBI1
Gene
PARVB
Ensembl
ENSG00000188677
Chromosome
22
Canonical length
364 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Actin filaments

OverviewNCBI Gene

This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9HBI1|PARVB
     1  MSSAPRSPTP RPRRMKKDES FLGKLGGTLA RKRRAREVSD LQEEGKNAIN SPMSPALVDV
    61  HPEDTQLEEN EERTMIDPTS KEDPKFKELV KVLLDWINDV LVEERIIVKQ LEEDLYDGQV
   121  LQKLLEKLAG CKLNVAEVTQ SEIGQKQKLQ TVLEAVHDLL RPRGWALRWS VDSIHGKNLV
   181  AILHLLVSLA MHFRAPIRLP EHVTVQVVVV RKREGLLHSS HISEELTTTT EMMMGRFERD
   241  AFDTLFDHAP DKLSVVKKSL ITFVNKHLNK LNLEVTELET QFADGVYLVL LMGLLEDYFV
   301  PLHHFYLTPE SFDQKVHNVS FAFELMLDGG LKKPKARPED VVNLDLKSTL RVLYNLFTKY
   361  KNVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARVB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
184 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 184 nTPM
  • tongue: 159 nTPM
  • heart muscle: 81 nTPM
  • bone marrow: 41 nTPM
  • adipose tissue: 40 nTPM
  • choroid plexus: 40 nTPM

Single-cell type

  • megakaryocytes: 1,193 nCPM
  • platelets: 752 nCPM
  • erythrocyte progenitors: 307 nCPM
  • myonuclei: 228 nCPM
  • pdcs: 214 nCPM
  • mast cells: 212 nCPM

Immune cell

  • plasmacytoid DC: 15 nTPM
  • total PBMC: 9.5 nTPM
  • myeloid DC: 7.2 nTPM
  • intermediate monocyte: 7.1 nTPM
  • classical monocyte: 6.5 nTPM
  • basophil: 6.4 nTPM

Brain region

  • cerebral cortex: 67 nTPM
  • thalamus: 57 nTPM
  • pons: 54 nTPM
  • amygdala: 52 nTPM
  • midbrain: 51 nTPM
  • hypothalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARVB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARVB as an antibody target. Whether an autoantibody or antibody against PARVB could matter depends on whether native PARVB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARVB is annotated at the cell surface, where native PARVB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARVB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARVB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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