Seroatlas · Human Serome Atlas

ILK

Scaffold protein ILK

Also known as: ILK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13418
Gene
ILK
Ensembl
ENSG00000166333
Chromosome
11
Canonical length
452 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Actin filaments,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q13418|ILK
     1  MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI
    61  NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV
   121  ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG
   181  TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP
   241  RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD
   301  MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA
   361  LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH
   421  VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ILK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
412 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 412 nTPM
  • seminal vesicle: 388 nTPM
  • colon: 385 nTPM
  • smooth muscle: 341 nTPM
  • endometrium: 332 nTPM
  • urinary bladder: 249 nTPM

Single-cell type

  • platelets: 1,249 nCPM
  • megakaryocytes: 835 nCPM
  • smooth muscle cells: 502 nCPM
  • hepatic stellate cells: 303 nCPM
  • decidual stromal cells: 282 nCPM
  • vascular smooth muscle cells: 261 nCPM

Immune cell

  • eosinophil: 419 nTPM
  • total PBMC: 402 nTPM
  • basophil: 316 nTPM
  • classical monocyte: 260 nTPM
  • NK-cell: 259 nTPM
  • intermediate monocyte: 258 nTPM

Brain region

  • choroid plexus: 49 nTPM
  • thalamus: 48 nTPM
  • basal ganglia: 43 nTPM
  • medulla oblongata: 42 nTPM
  • white matter: 42 nTPM
  • cerebellum: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ILK.

Disease | ImmuneIEDB

Conditions an epitope on ILK was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ILK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ILK as an antibody target. Whether an autoantibody or antibody against ILK could matter depends on whether native ILK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ILK is annotated at the cell surface, where native ILK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ILK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ILK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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