TES

Protein identityUniProt · HPA

UniProt accession

Q9UGI8

Gene

TES

Ensembl

ENSG00000135269

Chromosome

7

Canonical length

421 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane,Cell Junctions,Focal adhesion sites,Cytosol

OverviewNCBI Gene

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q9UGI8|TES
     1  MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE HDVLLSNEED
    61  RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA KKNVSINTVT YEWAPPVQNQ
   121  ALARQYMQML PKEKQPVAGS EGAQYRKKQL AKQLPAHDQD PSKCHELSPR EVKEMEQFVK
   181  KYKSEALGVG DVKLPCEMDA QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK
   241  LSMKEGDPAI YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR
   301  CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK PCYVKNHAVV
   361  CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG QKFMPVEGMV FCSVECKKRM
   421  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TES can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

186 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.55

gnomAD pLI

0

gnomAD missense Z

0.39

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cell population proliferation

Molecular functions

• cadherin binding
• RNA binding
• zinc ion binding

Cellular components

• cell junction
• cytosol
• focal adhesion
• nucleus
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, LIM-type
• PET domain
• PET testin
• Prickle/Espinas/Testin
• LIM domain
• PET Domain
• Testin, LIM domain 1
• Testin, LIM domain 2
• Testin, LIM domain 3

KeywordsUniProt

• Cell junction
• Cytoplasm
• LIM domain
• Metal-binding
• Repeat
• Zinc

InteractionsUniProt · HPA

Protein binding partners of TES in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ALKBH4
• ENAH
• GRIP1
• PXN
• ZYX
• ACTL7A